en تأثیر تزریق داخل صفاقی نانو ذرات مولیبدن بر تست های عملکردی کلیه در موش صحرایی نر Medical Laboratory and Animal Investigation Medical Laboratory and Animal Investigation مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#008080;"><strong>Background & Objective:</strong></span> Molybdenum trioxide nanoparticles (MoO₃ NPs) have widespread applications in industries. However, the toxic and non-toxic effects of MoO₃ NPs have not been fully investigated yet. In this study, effects of MoO₃ NPs on ovary function of female rats were studied.<br> <span style="color:#008080;"><strong>Materials & Methods:</strong></span> In this study, 21 female rats were randomly divided into three groups (n=7): the first group did not receive any treatment, the second one received normal saline, and the third group received 5 mg/kg MoO₃NPs in normal saline via intraperitoneal injection during a period of 28 days. Serum concentrations of estrogen, progesterone, luteinizing hormone, and follicle stimulating hormone were measured. Also, changes of ovaries, uterine weights, uterine, and length of uterine horns were studied.<span dir="RTL"></span><br> <span style="color:#008080;"><strong>Results: </strong></span>The serum level of estrogen in the MoO₃NPs exposed group was significantly attenuated; those of luteinizing hormones and follicle stimulating hormone were elevated while progesterone level change was insignificant. The weights of the right ovary and the uterine body decreased significantly in the exposed group.<br> <span style="color:#008080;"><strong>Conclusion: </strong></span>Our data showed that MoO₃ nanoparticle exposure could cause an imbalance of sex hormones and decrease in body and ovarian weights in thefemale rats.</span></span></p> Nanoparticles, Female rats, Reproduction 48 53 http://journal.zums.ac.ir/browse.php?a_code=A-10-2265-2&slc_lang=en&sid=1 Fardin Asadi فردین اسدی assadi_fardin@yahoo.com 5200319475328460046660 5200319475328460046660 No Dept. of Pediatrics, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Mansour Sadeghzadeh منصور صادق زاده sadeghzadeh@zums.ac.ir 5200319475328460046661 5200319475328460046661 No Dept. of Pediatrics, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Ahmad Jalilvand احمد جلیلوند Jalilvand @zums.ac.ir 5200319475328460046662 5200319475328460046662 No Dept. of Pathology, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Keivan Nedaei کیوان ندایی nedaee.k@gmail.com 5200319475328460046663 5200319475328460046663 No Dept. of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Yasamin Asadi یاسمین اسدی Yasamin1@zums.ac.ir 5200319475328460046664 5200319475328460046664 No National Nutrition of Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran Azam Heidari اعظم حیدری a.c.heidari@gmail.com 5200319475328460046665 5200319475328460046665 Yes Dept. of Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran