other بررسی اثر آگونیست گیرنده 5HT3 هیپوکامپ جانبی بر فراموشی ناشی از مورفین در موش‌های کوچک آزمایشگاهی مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:times new roman;"><span style="color:#008080;"><strong><em>Background and Objective:</em></strong></span> It has been shown that the opioidergic system exerts widespread effects on cognitive functions. Interactions between opioid and serotonin receptors have been reported in some brain structures such as the dorsal hippocampus, thus a functional interaction between opioids and serotonin seems possible concerning memory control. The purpose of this study was to assess the effects of CA1 5-HT3 receptor agonist on memory acquisition deficit induced by morphine.<br> <span style="color:#008080;"><strong><em>Materials and Methods: </em></strong></span>In this study, we used 96NMRI mice. These mice were divided into twelve equal groups that received different doses of 5-HT3recepto ragonist, different doses of morphine and a combination of morphine and serotonin 5-HT3 receptor agonist. Morphine was injected into the peritoneum, while 5-HT3 receptor agonist M-Chlorophenylbiguanide (M-chl) was administered via intra-hippocampal injection. A step-down passive avoidance test was used for the evaluation of memory.<br> <span style="color:#008080;"><strong><em>Results:</em></strong></span> Pre-training intra-peritoneal administration of morphine (5 mg/kg) induced amnesia. Moreover, pre-training intra-CA1 administration of 5-HT3 receptor agonist (M-Chl) (0.5 ng/mouse) impaired memory acquisition. Furthermore, intra-CA1 injection of M-Chl (0.005ng/mouse) reversed impairment of memory acquisition induced by morphine (5 mg/kg).<br> <span style="color:#008080;"><strong><em>Conclusion: </em></strong></span>The results demonstrated the existence of a synergistic effect between hippocampal 5-HT3 receptor agonists and opioidergic receptors.</span></span></p> Memory, 5-HT 3 agonist, Morphine, Mice, Passive avoidance 126 137 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-1101&slc_lang=other&sid=1 Fatemeh Doosti فاطمه دوستی 5200319475328460049809 6659-5812-0001-0000 Yes Dept. of Biology, Islamic Azad University, Central Tehran Branch, Tehran, Iran دانشگاه آزاد اسلامی واحد تهران مرکز، تهران Bahareh Pakpour بهاره پاکپور 5200319475328460049810 5200319475328460049810 No Dept. of Biology, Islamic Azad University, Central Tehran Branch, Tehran, Iran دانشگاه آزاد اسلامی واحد تهران مرکز، تهران Majid Navaeian مجید نوائیان 5200319475328460049811 5200319475328460049811 No Dept. of Biology, Islamic Azad University, Shahr-e- Rey Branch, Tehran, Iran دانشگاه آزاد اسلامی واحد شهر ری