en Medical Laboratory and Animal Investigation Medical Laboratory and Animal Investigation مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-family:times new roman;"><span style="font-size:14px;"><span style="color:#008080;"><strong>Background & Objective:</strong></span> <em>Securigera securidaca </em>is a medicinal plant used in Persian folk medicine to decrease blood sugar. Nevertheless, there is some controversy about its effects. The current study investigated the hypoglycemic activity of the aqueous seed extract of <em>S. securidaca</em>.<br> <span style="color:#008080;"><strong>Materials & Methods:</strong> </span>Sixty mature male Charles-River rats were categorized and divided randomly into 10 groups with two timeframes (7 and 14 days). To induce diabetes, rats were injected intraperitoneally with 7 mg/0.5 mL streptozotocin in normal saline per 100 g body weight. The aqueous seed extract of <em>S. securidaca </em>was given orally to rats daily (80 mg/0.5 mL in distilled water per 100 g of rat body weight). The blood sugar of rats was measured on the 7^th and 14^th days. Blood lipid indices and ALT, AST, and ALP plasma levels were measured after 14 days of treatment.<br> <span style="color:#008080;"><strong>Results: </strong></span>The findings showed that the <em>S. securidaca </em>aqueous seed extract had a significant effect on the blood sugar of rats after 7 and 14 days compared with the diabetic group. After 14 days, there was a significant difference in the weight of treated rats between the <em>S. securidaca </em>aqueous seed extract and diabetic groups. The <em>S. securidaca </em>aqueous seed extract had no significant effect on the blood lipid profiles of the treated rats. The AST enzyme levels were significantly higher in rats exposed to the seed extract than in the diabetic group.&nbsp;<br> <span style="color:#008080;"><strong>Conclusion:</strong> </span>Based on the results, <em>S. securidaca </em>seed extract had a significant effect in reducing the blood sugar of diabetic rats with no significant changes in lipid profiles. More studies are needed to explore in more detail the mechanism of this hypoglycemic effect.</span></span></p> Diabetes, Rat, Securigera securidaca, Streptozotocin 16 22 http://journal.zums.ac.ir/browse.php?a_code=A-10-4845-1&slc_lang=en&sid=1 Mohammad Azadbakht محمد آزادبخت azadbakhtm@hotmail.com 5200319475328460055571 5200319475328460055571 No Dept. of Pharmacognosy& Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Seyyedeh Atiyeh Ahmadi سیده عطیه احمدی atiehahmadi2@gmail.com 5200319475328460055572 5200319475328460055572 No Student Researches Committee, Ramsar Campus, Mazandaran University of Medical Sciences, Ramsar, Iran Nematollah Ahangar نعمت اله آهنگر dr.n.ahangar@gmail.com 5200319475328460055573 5200319475328460055573 Yes Dept. of Pharmacology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran