en Life Science Life Science مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:times new roman;"><span style="color:#008080;"><strong>Background & Objective:</strong></span> The potent antioxidant property of fullerene C₆₀ nanoparticles and their derivatives has been demonstrated in a wide range of <em>in vitro</em> and <em>in vivo</em> studies. Hence, we examined the effects of fullerene C₆₀&nbsp;on the oxidative stress parameters at brain and liver of rats in normal situation.<br> <span style="color:#008080;"><strong>Materials & Methods:</strong> </span>The study was performed in two groups of Wistar rats (each group, n = 6); normal and fullerene-treated normal animals. Treated rats received orally fullerene via oral gavage at dose of 1 mg/kg/day for 60 days. At termination of the study, the oxidative stress parameters were determined at brain and liver tissues, including the contents of glutathione (GSH) and malondialdehyde (MDA), and the activity of catalase (CAT) and superoxide dismutase (SOD). The t-test was used to analyze the data between two groups.<br> <span style="color:#008080;"><strong>Results: </strong></span>Fullerene C₆₀treatment did not change blood glucose of treated rats compared to untreated rats. Fullerene C₆₀ significantly increased the value of CAT activity (by 66%) and MDA levels (by 68%), whereas decreased SOD activity (by 33%) at liver of treated rats compared to untreated animals (P< 0.05). Fullerene administration significantly increased only CAT activity of brain in the treated rats (0.34&plusmn;0.10 U/mg protein) compared to untreated animals (0.12&plusmn;0.03 U/mg protein), (P<0.05).<br> <span style="color:#008080;"><strong>Conclusion: </strong></span>Our findings indicated that oral administration of fullerene C₆₀ nanoparticles differently changes the oxidative stress parameters in liver and brain at normal condition. It is suggested that these effects must be considered for application of these nanoparticles in various therapeutic purposes.</span></span></p> Antioxidant, Fullerene, Oxidative stress, Nanomaterials 8 15 http://journal.zums.ac.ir/browse.php?a_code=A-10-2301-5&slc_lang=en&sid=1 Fariba Namdar f_namdar_f@yahoo.com 5200319475328460048908 5200319475328460048908 No Dept. of Physiology and Medical Physics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Farideh Bahrami farideh_bahrami@yahoo.com 5200319475328460048909 5200319475328460048909 No Dept. of Physiology and Medical Physics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Zahra Bahari bahari_441@yahoo.com 5200319475328460048910 5200319475328460048910 No Dept. of Physiology and Medical Physics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Bahram Ghanbari ghanbari@sharif.edu 5200319475328460048911 5200319475328460048911 No Dept. of Chemistry, Sharif University of Technology, Tehran, Iran Seyed Ahmad Elahi Mohammadimohammadt@bmsu.ac.ir 5200319475328460048912 5200319475328460048912 No Dept. of General Surgery, School of Medicine, Alborz University of Medical Sciences, Tehran, Iran Mohammad Taghi Mohammadi Mohammadi.mohammadt@yahoo.com 5200319475328460048913 5200319475328460048913 Yes Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran