en Clinical Medicine Clinical Medicine مقاله مروری Review Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;">Coronavirus disease (COVID-19) can induce coagulopathy at the base of sepsis-induced coagulopathy (SIC), which is an important cause of death in these patients. Cytokine storm causes imbalance in coagulation and fibrinolytic system. A combination of hypercoagulability state, decrease or inhibition of fibrinolysis and endotheliopathy causes thromboembolic events. Underlying diseases such as diabetes and hypertension with a high rate of mortality in COVID-19 and some conditions like aging and obesity are the main disorders with hemostatic disturbance and increase of coagulopathy. Therefore, it seems that the combination of COVID-19 infection and these risk factors increase the risk of thromboembolic complications all together.</span></span></p> COVID-19, DIC, Coagulopathy, SarsCovid, Blood coagulation disorder 296 303 http://journal.zums.ac.ir/browse.php?a_code=A-10-5511-1&slc_lang=en&sid=1 Minoosh Moghimi mmoghimi@zums.ac.ir 5200319475328460055727 5200319475328460055727 No Dept. of of Hematology-Medical Oncology, Vali-e-Asr Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Kasra Khodadadi khodadadikasra2020@gmail.com 5200319475328460055728 5200319475328460055728 Yes Dept. of Internal Medicine, Vali-e-Asr Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Yousef Mortazavi youmort@yahoo.com 5200319475328460055729 5200319475328460055729 No Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran