en Clinical Medicine Clinical Medicine کارآزمایی بالینی Clinical Trials <p style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><b><span style="background:#2d7f8f"><span style="color:white">Background & Objective:</span></span><b> </b></b><span style="color:black">Depression and fatigue are common in patients with multiple sclerosis (MS). These complications exacerbate the symptoms of MS. This study aimed to determine the effect of self-acupressure on depression and fatigue in MS patients.</span><br> <b><span style="background:#2d7f8f"><span style="color:white"><span style="letter-spacing:-.1pt">&nbsp;Materials & Methods:</span></span></span></b> <span style="color:black"><span style="letter-spacing:-.1pt">In this randomized clinical trial (RCT), 96 participants from the MS Association of Mashhad, Iran completed the demographic form, the Depression, Anxiety Stress Scales (DASS-42), and the Fatigue Severity Scale (FSS). Then, they were randomly assigned to intervention and sham groups. Participants in the intervention group pressed the Shenmen and Yin Tang acupoints, and the sham group pressed 2.5 cm below the Shenmen and 3 cm above the Yin Tang acupoints for 15 minutes every day for one month. The participants completed the DASS-42 and FSS one hour after the final intervention in each group. Also, the chi-square, independent t-test, and paired t-test were used in the study.</span></span><br> <b><span lang="EN-IN"><span style="background:#2d7f8f"><span style="color:white">Results: </span></span></span>&nbsp;</b><span style="color:black"><span style="letter-spacing:-.1pt">The statistical analysis showed that the mean fatigue and depression scores were not significantly different between the two groups at the baseline (<i>P</i>>0.05). However, the mean scores of fatigue and depression significantly reduced in the intervention group compared to sham group one hour after the last intervention (<i>P</i><0.05). </span></span><br> <b><span style="background:#2d7f8f"><span style="color:white">Conclusion: </span></span>&nbsp;</b><span style="color:black">Self-acupressure is a simple and inexpensive intervention that may reduce depression and fatigue among MS patients.</span></span></span></p> Acupressure, Depression, Fatigue, Multiple sclerosis 276 283 http://journal.zums.ac.ir/browse.php?a_code=A-10-5382-2&slc_lang=en&sid=1 Hossein Rahimi hosseinrahimi92@yahoo.com 5200319475328460088759 5200319475328460088759 Yes Dept. of Nursing, School of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran Nasim Mehrpooya nasimmehrpooya@gmail.com 5200319475328460088760 5200319475328460088760 No Dept. of Nursing, School of Nursing and Midwifery, Neyshaboor University of Medical Sciences, Neyshaboor, Iran SeyyedAbolfazl Vagharseyyedin waghars@yahoo.com 5200319475328460088761 5200319475328460088761 No Dept. of Nursing, School of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran Hamidreza BahramiTaghanaki bahramihr@mums.ac.ir 5200319475328460088762 5200319475328460088762 No Dept.of Complementary and Chinese Medicine, Persian and Complementary Medicine School, Mashhad University of Medical Science, Mashhad, Iran