en Clinical Medicine Clinical Medicine گزارش موردی Case Report Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;">This study aimed to report histopathological features and serological outputs of the lung, heart and liver in a patient suffered from Coronavirus disease-2019 (COVID-19). A woman was admitted to the Razi Hospital, Rasht city, Iran with the symptoms of cough, dyspnea, fever and myalgia. She had also Parkinson&rsquo;s disease (PD); she had no history of respiratory, cardiovascular, renal and gastrointestinal diseases and alcohol consumption. COVID-19 infection was proved by the Real time-PCR (RT&ndash;qPCR) test. The required specimen was obtained from nasopharyngeal swab; however, lung radiologic findings revealed atypical signs of COVID-19. The patient expired after 8 days of admission. After death, needle biopsy was performed for histopathologic evaluation of the heart, lung and liver tissues. The RT&ndash;qPCR was performed to evaluate the presence of Coronavirus in the tissues. The pathological biopsies showed advanced alveolar damages in the lung, periportal inflammation in the liver, spread steatosis in the hepatocytes and moderate myocarditis in the heart. However, the RT-qPCR test was negative for these tissues, but alterations in the above-mentioned areas may be due to the secondary side effects of COVID-19 infection or pharmacological treatments.</span></span></p> COVID-19, Heart, Liver, Lung, Histopathology 183 188 http://journal.zums.ac.ir/browse.php?a_code=A-10-5561-1&slc_lang=en&sid=1 Erfan Naseri erfannaseryenr@gmail.com 5200319475328460056504 5200319475328460056504 No Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Fahimeh Mohammadghasemi parsahistolab@gmail.com 5200319475328460056505 5200319475328460056505 No Cellular & Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran Fahimeh Shams Fahime.shams@yahoo.com 5200319475328460056506 5200319475328460056506 Yes Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Sina Saliminasab Sinasaliimii@gmail.com 5200319475328460056507 5200319475328460056507 No Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Paridokht Karimian karimian@gums.ac.ir 5200319475328460056508 5200319475328460056508 No Dept. of Pathology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Morteza Rahbar Taramsari Rahbar_m46@yahoo.com 5200319475328460056509 5200319475328460056509 No Dept. of Forensic Medicine, School of Medicine, Guilan University of Medical Sciences. Rasht, Iran Siroos Kordrostami sirooskirdrostami@yahoo.com 5200319475328460056510 5200319475328460056510 No Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Ali Alavi Foumani Ali_alavi@gums.ac.ir 5200319475328460056511 5200319475328460056511 No Inflammatory Lung Diseases Research Center, Dept. of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Hossein Hemmati Drhossein_Hemmati@yahoo.com 5200319475328460056512 5200319475328460056512 No Dept. of General Surgery, Division of Vascular Surgery, Guilan University of Medical Sciences, Rasht, Iran Seyed Amineh Hojati Amineh_hojati@yahoo.com 5200319475328460056513 5200319475328460056513 No Gastrointestinal and Liver Diseases Research Center (GLDRC), Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Pirouz Samidoust pirozesamidoost@gmail.com 5200319475328460056514 5200319475328460056514 No Dept .of General Surgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Masoumeh Faghani mfaghani@gums.ac.ir 5200319475328460056515 5200319475328460056515 No Cellular & Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran