en Health Improvement Strategies Health Improvement Strategies کارآزمایی بالینی Clinical Trials <div style="text-align: justify;"><span style="color:#ffffff;"><strong><span style="background-color:#16a085;">Background and Objective:</span></strong></span><span style="background-color:#16a085;"> </span>Both duloxetine (DLX) and transcutaneous electrical nerve stimulation (TENS)&nbsp;are recommended as safe and effective treatments for diabetic peripheral neuropathic pain. However, these methods have not been compared. This study aimed to compare the efficacy of treatment by DLX and TENS in diabetic neuropathy pain relief.<br> <span style="color:#ffffff;"><strong><span style="background-color:#16a085;">Materials and Methods:</span></strong></span> This survey was performed on 60 eligible diabetic patients randomly divided into two groups of DLX (20, 40, and 60 mg/day for weeks 1, 2, and 3-12, respectively), and TENS (20 min,80 HZ, 50 Amp, 0.2 ms Square pulses 2-3 times sensory threshold). The participants were evaluated according to the numerical rating scale (NRS) after four and twelve weeks of treatment. Moreover, adverse drug reactions were documented during the study period.<br> <span style="color:#ffffff;"><strong><span style="background-color:#16a085;">Results:</span></strong><span style="background-color:#16a085;"> </span></span>Baseline demographic data had no significant difference between the two groups (<em>P</em>&ge;0.05). The average NRS scores were significantly lower in the DLX group in both measurement times. At the end of weeks four (<em>P</em>=0.01) and 12 (<em>P</em>=0.001), the trend of changes was significant from baseline to the third month (<em>P</em>=0.0001). No patient in the TENS group reported any side effects, while 18% did in the DLX group.<br> <span style="color:#ffffff;"><strong><span style="background-color:#16a085;">Conclusion:</span></strong></span> We found that both DLX and TENS were effective and safe for the management of painful diabetic neuropathy. The DLX seemed to be better, compared to TENS. However, in some conditions, such as drug intolerance or contraindication for medications, TENS could be a proper intervention.</div> Duloxetine, Painful diabetic neuropathy, TENS 286 292 http://journal.zums.ac.ir/browse.php?a_code=A-10-5613-1&slc_lang=en&sid=1 Bahram Naderi Nabi naderi_bahram@yahoo.com 5200319475328460066159 5200319475328460066159 No Anesthesiology Research Center, Department of Anesthesiology, Alzahra hospital, Guilan University of Medical Sciences, Rasht, Iran Alia Saberi Alia.saberi.1@gmail.com 5200319475328460066160 5200319475328460066160 No Dept. of Anesthesiology, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Babak Bakhshayesh Eghbali babak.bakh@gmail.com 5200319475328460066161 5200319475328460066161 No Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran Mozaffar Hosseininezhad dr.hoseinnezhad2020@gmail.com 5200319475328460066162 5200319475328460066162 Yes Dept. of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Gelareh Biazar gelarehbiazar1386@gmail.com 5200319475328460066163 5200319475328460066163 No Anesthesiology Research Center, Guilan University of Medical Sciences, Rasht, Iran Amir Abbasi Malekabadi amir.abbasi49@yahoo.com 5200319475328460066164 5200319475328460066164 No Anesthesiology Research Center, Guilan University of Medical Sciences, Rasht, Iran Ladan Mirmansouri L_mirmansoori@hotmail.com 5200319475328460066165 5200319475328460066165 No Student Research Committee, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran