en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><strong><span style="background-color:#008080;">Background and Objective:</span></strong></span> In December 2019, the outbreak of coronavirus disease 2019 (COVID-19) was observed in China, and it it spread rapidly throughout the world. Iranian traditional healers have applied different medicinal plants to prevent and treat COVID-19 based on their ethnopharmacological knowledge. This research aimed to investigate the ethnomedicinal knowledge of Iranian traditional healers to alleviate COVID-19 signs and symptoms.<br> <strong><span style="color:#ffffff;"><span style="background-color:#008080;">Materials and Methods:</span></span> </strong>Due to the limitations caused by COVID-19 pandemic, oral interviews were conducted by 26 traditional healers in Kerman and Zahedan cities in Iran. The names of recommended remedies for COVID-19 were collected, and their scientific names were authenticated. Next, a comprehensive research was carried out in the scientific databases. Finally, the herbs with any related proved properties to the respiratory system were listed; these herbs were probably useful for the COVID-19 prevention or treatment.<br> <strong><span style="color:#ffffff;"><span style="background-color:#008080;">Results:</span></span> </strong><em>Zataria multiflora, Althaea officinalis, Hordeum vulgare, Malva sylvestris, Matricaria chamomilla, Glycyrrhiza glabra, Allium sativum</em> and <em>Zingiber officinale</em> are considered as the most popular herbs by Iranian traditional healers for prevention and/or treatment of COVID-19. Recent studies have demonstrated that the above-mentioned herbs can be considered as good sources for alleviating the respiratory disorders such as influenza. Moreover, they have antitussive and immune-modulatory properties.<br> <span style="color:#ffffff;"><strong><span style="background-color:#008080;">Conclusion:</span></strong></span>&nbsp;Since there is no effective treatment for COVID-19, the capacity of different traditional medicine and ethnomedicine knowledge can be used as good sources for new drug discovery after accurate studies.</span></span></p> Iran, Ethnomedicine, Coronavirus, Pneumonia, Complementary therapies 238 245 http://journal.zums.ac.ir/browse.php?a_code=A-10-5632-1&slc_lang=en&sid=1 Maryam Azimi dr.azimm@gmail.com 5200319475328460064085 5200319475328460064085 No Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran Morteza Mojahedi mortazamojahedy@gmail.com 5200319475328460064086 5200319475328460064086 No Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Roshanak Mokaberinejad mokaberi@sbmu.ac.ir 5200319475328460064087 5200319475328460064087 No Dept. of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Fatemeh Sadat Hasheminasab hashemifa67@gmail.com 5200319475328460064088 5200319475328460064088 Yes Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran