en Pharmacology Pharmacology مقاله مروری Review Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="line-height:150%">In recent years,there has been a growing trend &nbsp;towards the use of herbal medicine in the treatment and prevention of diseases. Blood lipid-lowering drugs have many side effects. On the other hand, various studies have reported the effect of dill (<i>Anethum graveolens</i>) on the reduction of blood lipids in different ways. This study aimed to evaluate the effect of dill on reducing the blood lipid levels.</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="line-height:150%">In this systematic review, 12 papers that evaluated the effect of dill on blood lipid levels up to the end of 2018 were studied using valid key words such as Lipid Profile, Dill (<i>Anethum graveolens</i>), and Hyperlipidemia in Pubmed, Medlib, Scopus, Sciencedirect, Embase, Google Scholar, Magiran, IranMedex, and SID.</span> <span style="line-height:150%">The results of the studies were combined using the random effects method of meta-analysis. The heterogeneity of studies was investigated using Q statistics and I² Index.</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:150%"><span style="line-height:150%">In 12 studies, the weighted mean differences (WMDs) of cholesterol reduction (TC) before and after intervention were estimated to be WMD = -19.22 mg / dl (95% CI: -30.68, -7.77), triglyceride, WMD = -25.47 mg / dl (95% CI: -49.28, -1.66) and low density lipoprotein (LDL), WMD = -14.01 mg / dl (95% CI: -22.14, -5.89) which were statistically significant (<i>p</i> = 0.001). Meta-analysis after intervention in the case and placebo groups were (SMD=-2.71, 95% CI:-3.28,-1.06), for TC (SMD=-1.77, 95%CI:-2.71,-0.82) for TG and (SMD=-2.64, 95%CI:-3.88,-1.41)for LDL which indicated statistically significant reduction.</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="line-height:150%">Dill reduces cholesterol, triglyceride and low-density lipoprotein, but does not have a significant effect on high-density lipoprotein levels.</span></span></span></span></p> Lipid, Meta-analysis, Dill plant, Anethum graveolens, Review, Systematic, Hyperlipidemia 306 313 http://journal.zums.ac.ir/browse.php?a_code=A-10-5577-1&slc_lang=en&sid=1 Maryam Azimi m_deldar@yahoo.com 5200319475328460073530 5200319475328460073530 No Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran Maryam Deldar ma.deldarf@gmail.com 5200319475328460073531 5200319475328460073531 No Dept. of Biostatistics, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran Ardeshir Moayeri moayeri@razi.tums.ac.ir 5200319475328460073532 5200319475328460073532 No Dept.of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Kourosh Sayehmiri sayehmiri@razi.tums.ac.ir 5200319475328460073533 5200319475328460073533 Yes Dept. of Biostatistics, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran