en Clinical Medicine Clinical Medicine کارآزمایی بالینی Clinical Trials <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:150%"><span lang="EN-GB"><span style="line-height:150%">In- vitro fertilization (IVF) is one of the approved treatment options for infertility. Despite many progresses in this field, its success rate is about 20 -25%. Utilization of drugs which suppress or decrease uterine smooth muscle contraction before embryo transfer, theoretically can improve fertility by increasing implantation rate. This study was designed to evaluate nifedipine administration on embryo transfer success.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:150%"><span lang="EN-GB"><span style="line-height:150%">In this double blinded randomized clinical trial, ninety-eight infertile women from primary and secondary causes were included in two groups; one group received placebo and the other group a &nbsp;single dose of 20 mg nifedipine, both thirty minutes before embryo transfer. Primary outcome was defined as clinical pregnancy, and secondary outcomes as live birth, ectopic pregnancy, multiple gestation and abortion.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:150%"><span lang="EN-GB"><span style="line-height:150%">Clinical pregnancy occurred in eighteen patients in the placebo group and in seventeen patients in nifedipine group (OR = 0.91, 0.40-2.09 (95% CI)).<b> </b>Sixteen patients in placebo group and fourteen patients in nifedipine group had successful live births (OR = 0.82, 0.34-1.95 (95% CI)). Multiple gestation (OR = 1.71, 0.24- 11.78 (95% CI)) and abortion (OR = 0.46, 0.07-2.95 (95% CI)) were not different between the two groups. No side effect of drug occurred in any group.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:150%"><span lang="EN-GB"><span style="line-height:150%">A<b> </b>single dose of 20 mg nifedipine tablet administered thirty minutes before IVF had no effect on improving clinical pregnancy and live birth rate. Using higher doses, or different regimens in specific patients&rsquo; subgroups may have more effect on embryo transfer success.</span></span></span></span></span></p> In vitro fertilization,Infertility, Nifedipine 314 318 http://journal.zums.ac.ir/browse.php?a_code=A-10-5731-1&slc_lang=en&sid=1 Robabeh Mohammadbeigi robab20@yahoo.com 5200319475328460073534 5200319475328460073534 No Dept. of Obstetrics and Gynecology, Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran Behnam Hedayat bhedayat.thc@gmail.com 5200319475328460073535 5200319475328460073535 No Dept. of Cardiology, Tehran University of Medical Sciences, Tehran Heart Center, Tehran, Iran Ayda Fathollahpour ayda.fathollahpourmd@gmail.com 5200319475328460073536 5200319475328460073536 No Dept. of Obstetrics and Gynecology, Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran Solmaz Hedayat solmaz.hedayat@yahoo.com 5200319475328460073537 5200319475328460073537 Yes Dept. of Obstetrics and Gynecology, Akbar Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran