en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="unicode-bidi:embed"><span style="line-height:150%">Measurement of inflammatory markers and lactate dehydrogenase (LDH) may contribute to the evaluation of lung involvement severity. This study aimed to evaluate relationship between severity of primary lung involvement with highest level of erythrocyte sedimentation rate (ESR) and LDH in patients with COVID-19.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="unicode-bidi:embed"><span style="line-height:150%">This descriptive-analytical study was conducted on 123 patients with COVID-19 in Shahid Sadoughi Hospital<b>. </b>Data including age, gender, ESR (mm/h), LDH (U/L), and high-resolution Computed Tomography scan (HRCT) findings and hospitalization ward were extracted from medical records<b>. </b>The regression model was used to determine the relation between HRCT findings with LDH and ESR.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="unicode-bidi:embed"><span style="line-height:115%"><span style="line-height:115%">Mean LDH, ESR, and HRCT findings were 508.41&plusmn;224.65, 52.23&plusmn;29.56, and 37.17&plusmn; 22.18 respectively. A significant relation was seen between HRCT findings with highest level of LDH and ESR (<i>P</i>=0.001). A significant relation was observed between the highest levels of ESR and HRCT findings, regarding age, gender, and hospitalization wards (<i>P</i><0.01). There was a significant relation between the highest level of LDH and HRCT findings regarding age group and hospitalization wards (<i>P</i><0.01).</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="unicode-bidi:embed"><span style="line-height:115%"><span style="line-height:115%">A significant relation was seen between HRCT findings and highest levels of <span style="background:white"><span style="color:black">ESR and LDH in patients with COVID-19. Therefore</span></span>, it seems that assessment of </span><span style="background:white"><span style="line-height:115%"><span style="color:black">laboratory findings such as LDH and ESR can be helpful as </span></span></span><span style="line-height:115%">cost-effective markers instead of chest CT scan for predicting the severity of lung injury when the CT scan report is controversial.</span><span style="background:white"><span style="line-height:115%"><span style="color:black"> The relation between </span></span></span><span style="line-height:115%">HRCT findings with <span style="background:white"><span style="color:black">LDH and ESR were affected by age and hospitalization ward. </span></span>However, more studies should be conducted in this regard.</span></span></span></span></span></p> COVID-19, Erythrocyte sedimentation rate, High-resolution computed tomography, Lactate dehydrogenase 215 222 http://journal.zums.ac.ir/browse.php?a_code=A-10-5868-1&slc_lang=en&sid=1 Mohammad Cheraghi pour ch.mohammad.1373@gmail.com 5200319475328460073463 5200319475328460073463 No Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran Fatemeh Khaleghi f.khaleghi@ssu.ac.ir 5200319475328460073464 5200319475328460073464 No Dept. of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Nasim Namiranian namiranian.nasim@gmail.com 5200319475328460073465 5200319475328460073465 No Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Kazem Ansari kazemansari.1372@gmail.com 5200319475328460073466 5200319475328460073466 No Faculty of Medicine, Islamic Azad University, Yazd Branch, Yazd, Iran Mehrdad Mansouri mansory.mehrdad@yahoo.com 5200319475328460073467 5200319475328460073467 No Health System Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Nastaran Injinari nastaraninjinari@gmail.com 5200319475328460073468 5200319475328460073468 No Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Fatemeh Aghaeimeybodi Dr.meybodi@gmail.com 5200319475328460073469 5200319475328460073469 Yes Dept. of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran