en Clinical Medicine Clinical Medicine کارآزمایی بالینی Clinical Trials <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:150%"><span lang="EN-GB"><span style="line-height:150%">Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants are utilized for treatment of post stroke depression, reduced quality of life and poor compliance.&nbsp; This study compared the effects of sertraline and nortriptyline on the quality of life and depression in post-stroke patients.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:150%"><span lang="EN-GB"><span style="line-height:150%">This randomized double-blind trial was conducted on 56 stroke patients admitted to Valiasr Hospital in Zanjan, Iran, 2016. Patients were randomly allocated in two groups by simple randomization and received sertraline in one group, nortriptyline in the other and nobody received placebo.</span></span> <span lang="EN-GB"><span style="line-height:150%">Patients were screened for depression using BDI (II) questionnaire and</span></span><span style="line-height:150%"> those without </span><span lang="EN-GB"><span style="line-height:150%">depression were entered into study. During follow-up, patients completed a quality of life questionnaire named Nottingham Health Profile (NHP). Data were analysed using repeated measure and Bonferroni tests in SPSS </span></span><span style="line-height:150%">22</span><span lang="EN-GB"><span style="line-height:150%">. P<0.05 was considered statistically significant.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:150%"><span lang="EN-GB"><span style="line-height:150%">The mean age of patients in sertraline and nortriptyline groups were </span></span><span lang="EN-GB"><span style="line-height:150%">61.7 </span></span><span lang="EN-GB"><span style="line-height:150%">and </span></span><span lang="EN-GB"><span style="line-height:150%">63.6</span></span><span lang="EN-GB"><span style="line-height:150%">, respectively (P=0.194). </span></span><span lang="EN-GB"><span style="line-height:150%">No significant differences were observed for sex, marital status and education between two groups. The mean score of total quality of life and its dimensions decreased significantly during 6 months for both groups (P=0.001). The effect of sertraline in these reductions was not different from nortriptyline (P=0.60). The proportions of moderate or severe depression were 17.9% and 37.0% in sertraline and nortriptyline groups, respectively (P=0.24).</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:150%"><span lang="EN-GB"><span style="line-height:150%">Both sertraline and nortriptyline improved all aspects of quality of life and their effect on prevention of depression was similar. Therefore, the administration of sertraline or nortriptyline could be beneficial in post-stroke patients.</span></span></span></span></span></p> Sertraline, Nortriptyline, Stroke, Depression, Quality of life 319 326 http://journal.zums.ac.ir/browse.php?a_code=A-10-116-1&slc_lang=en&sid=1 Mina Shabani shabani@zums.ac.ir 5200319475328460073538 5200319475328460073538 No Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Mohammad Eshaghian dr.eshaghian79@yahoo.com 5200319475328460073539 5200319475328460073539 No Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Saeideh Mazloomzadeh smazloomzadeh@zums.ac.ir 5200319475328460073540 5200319475328460073540 Yes Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran