en Bionanotechnology Bionanotechnology مقاله مروری Review Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="color:black">In recent years, the use of nanoparticles (NPs), especially gold nanoparticles (GNPs) in radiotherapy, has been repeatedly studied by in-vitro, in-vivo experiments, and Monte Carlo simulation. Some studies declare that specific absorption of GNPs (with a higher atomic number) by cancerous cells increases radiations&rsquo; lethal effect compared to normal cells. This review article aimed to investigate the radiosensitizing effect of GNPs in cancer radiotherapy.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="color:black"><span style="letter-spacing:-.1pt">Research databases such as Web of Science, PubMed, and Scopus were examined from December 2019. All Gold Nanoparticles Radiation Therapy (GNRT) articles that studied the radiosensitization of gold nanoparticles in radiotherapy were involved in the assessment. Among 706 chosen articles, 52 documents were included in this investigation.</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="color:black"><span style="letter-spacing:-.1pt">The results of all these studies indicate that an increase in tumor mortality happens due to higher radiation absorption by nanoparticles entering the tumor; however, the relationship between the interaction of radiant energy and the size of gold nanoparticles is controversial.</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="color:black">This review article will discuss recent advances in the development of gold-based NPs to improve radiotherapy.</span></span></span></p> Gold Nanoparticle, Radiotherapy, Radio sensitization, Cancer 388 396 http://journal.zums.ac.ir/browse.php?a_code=A-10-6008-1&slc_lang=en&sid=1 Hossein Khosravi hkhosravi55@gmail.com 5200319475328460073644 5200319475328460073644 No Dept. of Radiology, Faculty of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran Amin Doosti-Irani a.doosti@umsha.ac.ir 5200319475328460073645 5200319475328460073645 No Dept. of Epidemiology, Hamadan University of Medical Sciences, Iran Hamid Bouraghi bouraghi@umsha .ac.ir 5200319475328460073646 5200319475328460073646 No Dept. of Health Information Technology, Faculty of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran Safoora Nikzad s.nikzad@umsha.ac.ir 5200319475328460073647 5200319475328460073647 Yes Dept. of Medical Physics, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran