en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:200%">Diabetic neuropathy pain is a common pain condition that has a major negative impact on health-related quality of life. However, despite many studies, it remains difficult to treat neuropathic pain. This study aimed to<b> </b>compare the efficacy of duloxetine with high tone power therapy (HTPT) in diabetic peripheral neuropathic pain.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:200%">The study is a single-centre, phase III clinical trial comparing the effect of HTPT versus treatment with duloxetine in diagnosed diabetic neuropathy patients between October 2019 to December 2020. In the case group, the HTPT was used with a four-second duration for 30 minutes daily. This treatment was continued twice a week for 10 sessions. The control group received duloxetine (30 mg/m2 once a day). The treatment response was assessed based on the VAS score.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:200%">The results showed that in both groups, there was a significant reduction in pain severity. In HTPT group, the average pain decreased from 7.36 to 4.6 and in duloxetine group from 7.7 to 4.8. During 8 measurements after the intervention; decrease in VAS score was higher in HTPT group (5.6) than in duloxetine group (6.5) in the first and fourth times after the intervention (P-Value=0.01). Further analysis demonstrated a positive correlation between pain severity and age so that, the pain also increases with &nbsp;advancing age.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:200%"><span style="line-height:200%">The results of the present study showed that both duloxetine and high tone therapies are safe and effective methods for neuropathic pain relief.</span></span></span></span></p> Diabetic Neuropathy, Duloxetine, TENS 316 322 http://journal.zums.ac.ir/browse.php?a_code=A-10-6068-1&slc_lang=en&sid=1 Mehrnoosh Zakerkish mehr.zaker@yahoo.com 5200319475328460077725 5200319475328460077725 Yes Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Zohre Ghafuri Zohre.ghafury@gmail.com 5200319475328460077726 5200319475328460077726 No Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Zahra Kosarian zkosarian@yahoo.com 5200319475328460077727 5200319475328460077727 No Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Masumeh Hessam hessam_pt81@yahoo.com 5200319475328460077728 5200319475328460077728 No Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Mohammadjafar ShaterzadehYazdi shaterzadeh-mj@ajums.ac.ir 5200319475328460077729 5200319475328460077729 No Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Shahram Rafie rafie-sh@ajums.ac.ir 5200319475328460077730 5200319475328460077730 No Dept. of Neurology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,Iran Seyed Mahmoud Latifi latifi-sm@ajums.ac.ir 5200319475328460077731 5200319475328460077731 No Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran