en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong>Genetic modifications in the adiponectin receptor 2 (AdipoR2) gene can affect phenotypes associated with insulin resistance and diabetes. The purpose of this study was to evaluate the possible role of genetic modifications in the AdipoR2 gene, to determine the frequency of genotypes and polymorphism alleles of this gene at rs11061971 (+219 A>T), and to investigate its correlation with type 2 diabetes (T2D) and its related metabolic profile.<br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="letter-spacing:-.1pt">In this case-control study, the single-nucleotide polymorphism (SNP) of AdipoR2 in 116 T2D patients and 102 controls was evaluated using RFLP PCR and FOK 1 enzyme. Fasting blood sugar, cholesterol, triglyceride, insulin, HDL-C, LDL-C and HbA1c were also measured and their correlation with the studied genetic modifications was assessed. The collected data were analyzed using Chi-square test and Hardy-Weinberg equation.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="letter-spacing:-.1pt">There was a significant association in AT and TT genotypes in rs11061971 (+219 A>T) with T2D. However, no significant difference was observed in the frequency of alleles between the case and control groups. In addition, in LDL-C and total cholesterol in the control group, there was a significant difference between AA and TT genotypes as well as with AA and AT genotypes. However, no correlation was found between the other studied serum parameters and the genotype of individuals in the rs1106197171 polymorphism.</span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong>It can be concluded that rs11061971 (+219 A>T) polymorphism is associated with T2D incidence. The findings suggest that AT and TT genotypes in this gene compared to AA genotype increase the risk of diabetes.</span></span></p> Health Status, Quality of Life, SF-36 questionnaire, Systemic Lupus Erythematosus 348 357 http://journal.zums.ac.ir/browse.php?a_code=A-10-6387-1&slc_lang=en&sid=1 Zahra Rezaieyazdi Rezaieyazdiz@mums.ac.ir 5200319475328460079003 5200319475328460079003 No Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Sahebari Sahebarim@mums.ac.ir 5200319475328460079004 5200319475328460079004 No Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Zahra Fatehi FatehiZ911@mums.ac.ir 5200319475328460079005 5200319475328460079005 No Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Rozita Khodashahi Khodashahir@mums.ac.ir 5200319475328460079006 5200319475328460079006 No Dept. of Infectious Diseases and Tropical Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mandana Khodashahi mkhodashahi53@gmail.com 5200319475328460079007 5200319475328460079007 Yes Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran