en Clinical Medicine Clinical Medicine کارآزمایی بالینی Clinical Trials <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="line-height:150%">Regarding the high prevalence of sepsis, it is important to discover methods to control this condition. Valuable effect of vitamin C in vasopressin synthesis is demonstrated, moreover, its antioxidant effect reduces vascular infiltration. Therefore, the beneficial effects of vitamin C in prognosis of the patients who have been admitted to Vali-e- Asr hospital</span> in <span style="line-height:150%">Zanjan, Iran with the diagnosis of sepsis have been evaluated.</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="line-height:150%">This cross sectional study was</span> <span style="line-height:150%">planned on patients with sepsis who have been admitted to the infectious ward of Vali-e-Asr hospital in Zanjan. Patients with sepsis above 18 years old from June to March 2020 have been included in this study. Data of patients whom have received intravenous vitamin C, 25 mg/kg/24h for 4 days, and patients without reception vitamin C was collected from their files. Their demographic, clinical and para clinical information were collected, then the information was analyzed.</span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:150%"><span style="line-height:150%">54 patients (26 received vitamin C and 28 did not receive vitamin C) were enrolled in this study. Considering that the two groups were matched from the beginning of the study, no statistically significant difference was found between the two groups of patients in demographic characteristics. Furthermore, there were no significant differences in the sepsis induced complications, e.g. laboratory findings, mean days of hospitalization in ICU and SOFA score. </span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="line-height:150%">Our findings demonstrated that no clear statistically significant difference was found between the two groups of control and vitamin C received groups; nonetheless for precise conclusion more studies with larger groups are required.</span></span></span></span></p> Sepsis, Vitamin C, Prognosis, Septic Shock, Sofa Score 364 371 http://journal.zums.ac.ir/browse.php?a_code=A-10-40-1&slc_lang=en&sid=1 Afsaneh Karami dr.akarami@yahoo.com 5200319475328460077753 5200319475328460077753 No Dept. of Infectious Diseases, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Fattaneh Fallahpour fat.din5959@gmail.com 5200319475328460077754 5200319475328460077754 No Dept. of Infectious Diseases, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Nima Motamed nima.motamed@gmail.com 5200319475328460077755 5200319475328460077755 No Dept. of Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Mohammad Reza Jafari jafari@zums.ac.ir & jafarimrj@yahoo.com 5200319475328460077756 5200319475328460077756 Yes Dept. of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran