Journal of Advances in Medical and Biomedical Research

en Evaluation of the Effect of Capparis spinosa L. on Cisplatin-Induced Liver Injury in Male Rats based on Persian Medicine Medical Biology Medical Biology مقاله پژوهشی Original Research Article Background and Objective: Cisplatin as a chemotherapy drug causes liver damage by increasing inflammation. Hepatoprotective agents with antioxidant properties can be useful for preventing this complication. Capparis spinosa, as a natural antioxidant source, can help to eliminate these productions. The purpose of this study was to determine the effect of two different doses of hydroalcoholic extract of Capparis seed on cisplatin-induced liver damages in rats. Materials and Methods: Forty male rats were divided into five groups (the control group, Cis (cisplatin) group, 200 C/S (Capparis spinosa), Cis + 50 C/S, and Cis + 100 C/S). Biochemical and histopathological evaluations were made. At the end of the study, all animals were euthanized with a CO2 gradient. Statistical analyses were performed through Graph Pad Prism Statistics software 9.1.2. The level of significance was set at p < 0.05. Results: Liver function tests, antioxidant and inflammatory markers and histopathological changes were evaluated. Significant changes in the pathology results were noticeable. Central vein, portal vein and bile duct diameter, thickness of the hepatic artery wall, and hepatic sinusoids were significantly increased in the Cis and 200 C/S-fed groups, compared to the controls, and also changes in favor of improvement were evident in the treatment groups, especially in the Cis + 100 C/S group compared to the Cis and 200 C/S groups. Conclusion: Based on pathology results, treatment with C. spinosa seed extract may be helpful in preventing cisplatin hepatotoxicity. Drug-Induced Liver Injury, Capparis spinosa L., Cisplatin, Medicine, Persian 398 406 http://journal.zums.ac.ir/browse.php?a_code=A-10-5620-2&slc_lang=en&sid=1 Sonya Heydari S.heydari9701@zums.ac.ir 5200319475328460077772 5200319475328460077772 No Dept. of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Seyed Hojjat Hosseini h.hosseini@zums.ac.ir 5200319475328460077773 5200319475328460077773 No Dept. of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Koorosh Kamali drkamali@zums.ac.ir 5200319475328460077774 5200319475328460077774 No Dept. of Public Health, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran Saeed Sardari ssardari@zums.ac.ir 5200319475328460077775 5200319475328460077775 No Dept. of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Negin Parsamanesh neginparsa.684@gmail.com 5200319475328460077776 5200319475328460077776 No Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Narjes Khavasi nxavasi@zums.ac.ir & nxavasi@gmail.com 5200319475328460077777 5200319475328460077777 Yes Dept. of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran