Journal of Advances in Medical and Biomedical Research

en Adverse Pregnancy Outcomes and Rheumatoid Arthritis: a Retrospective Matched Cohort Study Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article Background and Objective: Rheumatoid Arthritis (RA) is an autoimmune-driven chronic systemic inflammatory disease. It could result in miscarriage, pre-eclampsia, and preterm labor, among other unfavorable pregnancy outcomes. Thus, this study was conducted to investigate the adverse pregnancy outcomes in pregnant women with RA. Materials and Methods: Two cohorts of pregnant women with and without RA referred to the Ayatollah Mousavi Hospital's Gynecology and Obstetrics Clinic in Zanjan, Iran, during 2019-2020 were enrolled in a retrospective matched cohort study. Using their medical records, each participant completed a checklist of study variables. We used binary Logistic regression, chi-square test, Analysis of Variance, and independent samples t-test to analyze data using SPSS v.23. Results: The study included 280 pregnant women. The mean age of the RA and control group (pregnant women without RA) was 32.4 ± 6.6 and 29.5 ± 6.7 years, respectively. The most prevalent adverse outcome was spontaneous abortion (54, 19.28%), which was significantly higher in the RA group (25% vs. 13.6%, P= 0.015). Cesarean section (24.3% vs. 10.7%, P= 0.003) and low birth weight (LBW) were both significantly higher in the RA group (15% vs. 5%, P= 0.005). RA increased the probability of spontaneous abortion, cesarean section, and LBW by more than 1.3 (odds ratio, 1.38; 95% CI, 0.45-5.46; P= 0.017), 2.2 (odds ratio, 2.24; 95% CI, 1.29-6.54; P =0.004), and 2.6 (odds ratio, 2.67; 95% CI, 1.86-7.05; P= 0.008) times, respectively. Conclusion: Pregnant women with RA are more likely to experience spontaneous abortion, cesarean section, and having LBW infants comparing to pregnant women without RA. Rheumatoid Arthritis, Pregnancy, Cesarean Section, Spontaneous Abortion, Low Birth Weight 549 556 http://journal.zums.ac.ir/browse.php?a_code=A-10-6634-1&slc_lang=en&sid=1 Alireza Sadeghi rsadeghi@zums.ac.ir 5200319475328460079161 5200319475328460079161 No Dept. of Internal Medicine, School of Medicine, Vali-e-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Mina Rostami Mina.rostami1373@gmail.com 5200319475328460079162 5200319475328460079162 No Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Nazila Nasiri Nazila.nasiri83@yahoo.com 5200319475328460079163 5200319475328460079163 No Dept. of Internal Medicine, School of Medicine, Vali-e-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Robabeh Hatami r.hatami@zums.ac.ir 5200319475328460079164 5200319475328460079164 No Dept. of Obstetrics and Gynecology, School of Medicine, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Arezoo Karimi Moghaddam akarimimoghaddam80@gmail.com 5200319475328460079165 5200319475328460079165 No Dept. of Ophthalmology, School of Medicine, Vali-E-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Zhaleh Karimi Moghaddam zhkarimi@zums.ac.ir 5200319475328460079166 5200319475328460079166 No Dept. of Radiation Oncology, School of Medicine, Vali-e-asr Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Alireza Zeraatchi zeraatchi.zums@gmail.com 5200319475328460079167 5200319475328460079167 Yes Dept. of Emergency Medicine, School of Medicine, Valiasr-e-Asr Hospital, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran