en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:#2d7f8f"><span style="color:white">Background&Objective:</span></span></span></b><span style="color:black">Occurrence of maternal or fetal complications during pregnancy may be related to development of postpartum thyroid dysfunction based on the underlying thyroid autoimmune status.&nbsp; The purpose of this study wasto investigate the incidence of thyroid dysfunction after delivery in euthyroid mothers who have experienced adverse pregnancy outcomes.</span></span></span><br> <span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="background:#2d7f8f"><span style="color:white"><span style="letter-spacing:-.1pt">Materials&Methods:</span></span></span></b> <span style="color:black"><span style="letter-spacing:-.1pt">Among</span></span> <span style="color:black"><span style="letter-spacing:-.1pt">387 euthyroid pregnant women, 118 experienced adverse pregnancy outcomes out of which only 96 subjects completed the study. The level of thyroperoxidase antibody in the first week after delivery and thyroid function tests including Total T4, T3RU and TSH three months after delivery were measured by electrochemiluminescence immunoassay method. SPSS version 22 was used to analyze the data and the significance level was defined as p<0.05.</span></span></span></span><br> <span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="background:#2d7f8f"><span style="color:white">Results:</span></span></b>Thyroperoxidase antibody was positive in 14 participants (14.6%). Overall maternal and fetal complications in the group with positive thyroperoxidase antibody were more than the group without this antibody (p<0.001). Total T4 level was significantly (p=0.02) higher in the group with negative thyroperoxidase antibody (8.03&plusmn;1.91) comparing with the positive antibody group (6.72&plusmn;1.96). Overt hypothyroidism was the only thyroid dysfunction that had a significant relationship with thyroid autoimmune status three months after delivery (p=0.02).</span></span><br> <span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><b><span style="background:#2d7f8f"><span style="color:white">Conclusion:</span></span></b>This study indicates the possible occurrence of thyroid dysfunction after delivery in euthyroid mothers who have experienced maternal or fetal pregnancy complications.</span></span> Thyroid function tests, Postpartum, Pregnancy outcome, Autoimmunity 101 110 http://journal.zums.ac.ir/browse.php?a_code=A-10-1811-5&slc_lang=en&sid=1 Fattaneh Bassami fattanehbassami@yahoo.com 5200319475328460089286 0009-0001-3400-0776 No Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Hossein Chiti h.chiti@yahoo.com 5200319475328460089287 5200319475328460089287 Yes Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Shahin Besharati Kivi shahin.besharati@zums.ac.ir 5200319475328460089288 5200319475328460089288 No Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Farnaz Mohammadian mohamadian@zums.ac.ir 5200319475328460089289 5200319475328460089289 No 3. Department of Obstetrics and Gynecology, Zanjan University of Medical Sciences, Zanjan, Iran Aisa Paknejad paknejad.aisa@gmail.com 5200319475328460089290 5200319475328460089290 No Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Ramezan Fallah rfv@zums.ac.ir 5200319475328460089291 5200319475328460089291 No 4. Department of Statistics and Epidemiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran