en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="unicode-bidi:embed"><span style="line-height:150%">Myocardial infarction (MI) is one of the highest leading causes of death worldwide. Many biomarkers are universally accepted in clinical practice as crucial diagnostic biomarkers in acute MI. The current study aims to introduce new sensitivity biomarkers to aid the diagnosis and to facilitate faster decision-making in the emergency department.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="unicode-bidi:embed">A total of <span style="line-height:150%">50 patients</span>,<span style="line-height:150%"> diagnosed with acute myocardial infarction, in Nasiriyah Heart Center, and 30 age-matched healthy </span>individuals were studied<span style="line-height:150%">. Serum Cardiac Troponin I (cTnI), Myoglobin (MYO), Creatine kinase (CK-MB), Procalcitonin (PCT), Heart-type fatty acid binding protein (H-FABP), Lipoprotein-associated phospholipase A2 (Lp-PLA2), High sensitive C reactive protein (hsCRP), were determined by electro-chemiluminescence immunoassay. Blood sugar and serum total cholesterol, triglycerides, LDL, VLDL, and HDL were determined by using Cobas C311 photometric assays.<b> </b>Serum</span> <span style="line-height:150%">IL-6 was assayed by electro-chemiluminescence immunoassay, while, IL-9, IL-1&beta;, and TNF-&alpha; were assayed by ELISA.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:150%"><span style="unicode-bidi:embed"><span style="line-height:150%">In comparison with healthy control, patients with acute MI showed significant elevation of the serum levels of cTnI, CK-MB, MYO, CRP, H- FABP, PCT, TNF-&alpha;, IL-1&beta;, IL-9, and IL-6.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="unicode-bidi:embed"><span style="line-height:150%">The present study suggests that, in addition to cTnI, CK-MB, and MYO, many other mediators such as CRP, H-FABP, PCT, and cytokines are sensitive to the diagnosis of MI. Furthermore, using human monoclonal antibodies that selectively neutralize cytokines may provide additional insight into cytokines-targeted therapies.</span></span></span></span></span></p> CK-MB, CRP, H-FABP, IL-6, Lp-PLA2MI, Myoglobin, PCT, Troponin 407 414 http://journal.zums.ac.ir/browse.php?a_code=A-10-6839-1&slc_lang=en&sid=1 Muayad Hussein Amer muayd.hussan@yahoo.com 5200319475328460077778 5200319475328460077778 No Dept. of Medicine, Ibn El Jazzar Faculty of Medicine, University of Sousse, Sousse, Tunisia Samia Ernez Hajri samiaernezhajri@live.fr 5200319475328460077779 5200319475328460077779 Yes Dept. of Cardiology, Farhat Hached Hospital-Sousse, Ibn El Jazzar Faculty of Medicine, University of Sousse, Sousse, Tunisia Ali Esmail Al-Snafi aboahmad61@yahoo.com & dr.aliasm@utq.edu.iq 5200319475328460077780 5200319475328460077780 No Dept. of Pharmacology, College of Medicine, University of Thi-Qar, Thi-Qar, Iraq