Journal of Advances in Medical and Biomedical Research

en Comparison of the Effect of 5 and 10% Intranasal Lidocaine Spray on Improving Headache in Patients with Head Trauma Referring to the Emergency Department Clinical Medicine Clinical Medicine کارآزمایی بالینی Clinical Trials Background & Objective: Headache is a common complaint among traumatic patients referring to the emergency department.  To improve headache in these patients, an effective, fast-acting, accessible and inexpensive drug without a significant effect on the level of consciousness and vital signs is highly needed.    Materials & Methods:  In this double-blind randomized clinical trial (RCT) on patients with head trauma, Group A was given 5% intranasal lidocaine spray while group B was prescribed 10% intranasal lidocaine spray to improve headache. Headache severity was checked based on numeric pain scale (NPS) before drug administration and then at 5, 15, 30 minutes and plus 1 hour post-drug administration, along with patient satisfaction and possible side effects. Finally, the obtained data were analyzed using SPSS 23 software. Results: According to the data, the maximum reduction in headache occurred 5 minutes after the drug administration. There was a significant difference between the two groups in terms of satisfaction (P value = 0.022), where group A had 100% high satisfaction while group B had 87.5% high satisfaction and 12.5% had moderate satisfaction. Of the 80 patients in the study, 3 patients had tearing complications after medication administration, which resolved after 5 minutes, and one case had nasal mucosal anesthesia, which improved after 15 minutes.   Conclusion: According to the results of this study, the use of 5% intranasal lidocaine spray is as effective as 10% intranasal lidocaine spray in relieving headache in traumatic patients and was associated with greater satisfaction and fewer complications.   Head trauma - Headache - Intranasal Lidocaine Spray 202 208 http://journal.zums.ac.ir/browse.php?a_code=A-10-6918-2&slc_lang=en&sid=1 fatemeh tabatabaei f.tabatabaei@ssu.ac.ir 5200319475328460086628 5200319475328460086628 No department of Emergency Medicine, School of Medicine, Shahid sadoughi University of Medical Sciences, Yazd, Iran ali mellat ali_mellat@ssu.ac.ir 5200319475328460086629 5200319475328460086629 No Department of Neurology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran alireza esmaeli alirezaesmaeili1@ssu.ac.ir 5200319475328460086630 5200319475328460086630 Yes department of Emergency Medicine, School of Medicine, Shahid sadoughi University of Medical Sciences, Yazd, Iran naser Mohammad Karimi Nmkarimi1310@gmail.com 5200319475328460086631 5200319475328460086631 No Department of Emergency Medicine, School of Medicine, Shahid sadoughi University of Medical Sciences, Yazd, Irad mehrnaz nikouyeh MEhrnaznikouyeh@gmail.com 5200319475328460086632 5200319475328460086632 No department of Emergency Medicine, School of Medicine, Shahid sadoughi University of Medical Sciences, Yazd, Iran