en Medical Biology Medical Biology مقاله پژوهشی Original Research Article <span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:#2d7f8f"><span style="color:white">Background & Objective:</span></span></span></b><b> </b><span style="font-size:9.0pt">The relationship between vitamin D receptor (VDR). Polymorphisms, and diabetes remain uncertain. This study aimed to examine the potential correlation between type 2 diabetes mellitus (T2DM) and rs739837 single nucleotide polymorphism (SNP) in the Mazandaran province population.</span></span></span><br> <span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="font-size:9.0pt"><span style="background:#2d7f8f"><span style="color:white"><span style="letter-spacing:-.1pt">Materials & Methods:</span></span></span></span></b> <span style="font-size:9.0pt">A case-control study was conducted, involving 100 individuals diagnosed with T2DM and 100 healthy controls, all residents of Mazandaran province. The extraction of genomic DNA and rs739837 polymorphism was genotyped using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method.</span></span></span><br> <span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="font-size:9.0pt"><span style="background:#2d7f8f"><span style="color:white">Results: </span></span></span></b><span style="font-size:9.0pt">The data indicated a significant association between GT genotype and a decreased risk of T2DM (OR= 0.5135, 95%CI= 0.2759 to 0.9559, P=0.0355). Moreover, individuals carrying T allele showed a reduced likelihood of progressing T2DM (OR= 0.4657, 95%CI= 0.2564 to 0.8461, P=0.0121).</span><span style="font-size:12.0pt"><span style="background:yellow"></span></span></span></span><br> <span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="background:#2d7f8f"><span style="color:white">Conclusion: </span></span></span></b><span style="font-size:9.0pt">The findings suggested that rs739837 polymorphism in the VDR gene may serve as a protective factor against T2DM in the studied population. Further research with larger samples is needed to confirm these results across different populations.</span><span style="font-size:9.0pt"><span style="background:yellow"></span></span></span></span><br> &nbsp; VDR gene, rs739837, Genetic polymorphism, T2DM 361 369 http://journal.zums.ac.ir/browse.php?a_code=A-10-2454-2&slc_lang=en&sid=1 Naeme Mohammadi Naemehmohammadi1998@gmail.com 5200319475328460089559 5200319475328460089559 No Department. of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran Bahman Eslami bejadidi@gmail.com 5200319475328460089560 5200319475328460089560 No Department. of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran Bagher Seyedalipour b.alipour81@gmail.com 5200319475328460089561 5200319475328460089561 Yes Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, Babolsar, Iran Ehsan Joz Jalalian ehsan.jalalian2023@gmail.com 5200319475328460089562 5200319475328460089562 No Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, Babolsar, Iran