Journal of Advances in Medical and Biomedical Research

en A Comparison between the Impacts of Continuous and Intermittent Intravenous Pantoprazole Injection on High Risk Upper Gastrointestinal Bleeding Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article Background & Objective:  Although higher age was previously associated with upper gastrointestinal bleeding (UGIB), rebleeding due to low PH has been recently considered as a crucial prognosis factor. In this regard, pantoprazole, a Proton pump inhibitor (PPIs), along with endoscopy was applied in high-risk patients. As it is an undeniably momentous approach to discover the best PPIs injection method, the advantages and disadvantages of continuous and intermittent PPIs’ infusion were compared in high-risk UGIBs patients. Materials & Methods: Eighty selected patients were randomly divided into two equal groups. In the continuous infusion, there were 6 and 34 patients with adherent clot ulcers and visible vessel ulcers without bleeding; however, 2 and 38 patients with these ulcers were present in the intermittent infusion group in turn. After three days, ulcers, packed cells, and surgery needs were evaluated between the two groups.  Results: After 72 hours of treatment, 29, 3 and 8 patients in the continuous group showed clean base, flat pigmented spot, and visible vessel ulcer with bleeding, respectively. Whereas in the intermittent group, these records were 35, 5 and 0, respectively (p≤0.028). The number of patients in the continuous infusion group with a visible vessel ulcer was significantly higher (p>0.028). A significant difference was also observed between the groups in terms of length of hospitalizations (p≤0.001) with no mortality.  Conclusion: Based on the findings, the intermittent infusion of PPIs is obviously superior over continuous mode. However, further studies with a larger population are recommended to discover the merits and drawbacks of this method in high-risk UGIBs.   Upper gastrointestinal bleeding, Proton pump inhibitors, Continuous infusion, Intermittent 185 190 http://journal.zums.ac.ir/browse.php?a_code=A-10-6371-2&slc_lang=en&sid=1 Sattar Jafari jafari.sattar@gmail.com 5200319475328460086623 5200319475328460086623 No 1. Department of Internal Medicine, Vali-e- Asr Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Mohammad Sadegh Novin zolmat.be.noor@gmail.com 5200319475328460086624 5200319475328460086624 No 1. Department of Internal Medicine, Vali-e- Asr Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran fatemeh salarpour fatemeh.salarpour.1@ulaval.ca 5200319475328460086625 5200319475328460086625 Yes Department of Immunology-Microbiology, Laval University, Quebec, Canada.