Journal of Advances in Medical and Biomedical Research

en The Comparison of the Efficacy of Agomelatine and Sertraline Medications in the Treatment of Depressive Symptoms in Patients with Heart Failure: A Randomized Double-Blind Clinical Trial Epidemiologic Studies Epidemiologic Studies کارآزمایی بالینی Clinical Trials Objectives & Aims: Depression impacts 20% of heart failure (HF) patients, doubling their mortality risk and tripling non-compliance with treatment. This study compares the effectiveness of Agomelatine and Sertraline in treating depression in these patients. Methods: This double-blind, randomized clinical trial study was conducted on 58 patients referred to Babol University of Medical Sciences clinics. The participants were divided into two groups of 29 samples; one group was treated with Sertraline (half a 25 mg tablet) and the other with Agomelatine (a daily 25 mg tablet) for 12 weeks. Evaluation of depression scores before the intervention and in weeks 4, 8, and 12 was done by BDI-II and HAM-D questionnaires. Results: The mean age of the patients was 61.59±15.32 years, and 17 (58.6%) participants were female. An analysis of the BDI-II and HAM-D questionnaire scores in both groups revealed a significant effect of time (P<0.001), indicating that scores on both questionnaires decreased significantly over time. However, the treatment group's effect was insignificant (p=0.538, p=0.412). Regarding side effects, no significant differences were observed between the two medications (all P>0.05). Conclusion: This study's findings indicate that Agomelatine and Sertraline are not superior in managing depression in HF patients. Most secondary outcomes and side effect profiles were similar between the two treatment groups, with no significant differences observed. Additionally, the efficacy of both medications remained consistent across HF patients with varying disease severity. Depression, Sertraline, Agomelatine, Heart Failure 1 10 http://journal.zums.ac.ir/browse.php?a_code=A-10-7038-1&slc_lang=en&sid=1 Naghmeh Ziaie ziaiexn@yahoo.com 5200319475328460082793 5200319475328460082793 No Department of Cardiology Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Angela Hamidia hale.ghaem.sums@gmail.com 5200319475328460082794 5200319475328460082794 No Department of Psychiatry, Social Determinants of Health Research Center, Babol University of Medical Sciences, Babol, Iran Azadeh Ramezani zahramaleki642@gmail.com 5200319475328460082795 5200319475328460082795 No Department of Psychiatry, School of Medicine, Babol University of Medical Sciences, Babol, Iran Saeed Abrtan maleki5146@gmail.com 5200319475328460082796 5200319475328460082796 No Department of Psychiatry, School of Medicine, Babol University of Medical Sciences, Babol, Iran Hoda Shirafkan Hodashirafkan@gmail.com 5200319475328460082797 5200319475328460082797 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical sciences, Babol, Iran Hirbod Hadizadeh Hirbod.hadizadeh@yahoo.com 5200319475328460082798 0009-0009-8672-3122 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Negin Tavakoli negin.t197@gmail.com 5200319475328460082799 0009-0008-9904-4658 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Romina Hamzehpour rominahamzehpour@gmail.com 5200319475328460082800 5200319475328460082800 Yes Department of Psychiatry, Social Determinants of Health Research Center, Babol University of Medical Sciences, Babol, Iran