Journal of Advances in Medical and Biomedical Research

en Cefaly Neurostimulation Therapy For Intractable Migraine Patients Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article Background and Objective: Migraine is a common neurological disorder affecting one billion people worldwide, causing disability, reduced quality of life, and high economic costs. Medical treatments have often limited efficacy and side effects. Non-pharmacological options such as trigeminal nerve stimulation with devices such as Cefaly® offer alternatives. This study assesses effectiveness of Cefaly®'s in reducing uncontrolled migraine symptoms alongside standard medications. Methods: This study included 20 patients with migraine, with or without aura, intractable to conventional treatments. Participants used the Cefaly® device in addition to regular medication for external trigeminal nerve stimulation on the forehead. Migraine frequency, severity, and duration were assessed over one month using pre- and post-intervention questionnaires, with data analyzed by nonparametric methods due to the small sample size. Results: The proportion of participants experiencing severe attacks dropped from 45% to 15% (P = 0.037). The frequency of attacks was reduced, with the percentage of participants having 3-5 attacks per month falling from 75% to 45%, and those with more than 5 attacks per month declining to 0% (P = 0.038). Attack duration also decreased, with a reduction in attacks lasting 12-24 hours from 35% to 20%, and those lasting more than 24 hours from 45% to 15% (P = 0.002). Conclusion: Cefaly® could effectively reduce the severity, frequency, and duration of headaches in patients who do not respond conventional treatments, suggesting it as a promising non-pharmacological option. Further research with larger samples and longer follow-up is needed to confirm these findings and assess long-term efficacy. Migraine, Transcutaneous Nerve Stimulation, Trigeminal Nerve, Nerve Stimulation 73 80 http://journal.zums.ac.ir/browse.php?a_code=A-10-7141-1&slc_lang=en&sid=1 Mahdi Ahani mahdi.ahani14@gmail.com 5200319475328460082840 0009-0002-5800-7080 No Student Research Committee, Department of Neurology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Pouya Karami ar.ghreishy@gmail.com 5200319475328460082841 0009-0007-5214-0047 No Student Research Committee, Department of Neurology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Tina Ehrami ar.ghoreishy@gmail.com 5200319475328460082842 0009-0006-3114-5108 No Student Research Committee, Department of Neurology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Abdoreza Ghoreishi ar.ghreishy@gmail.com 5200319475328460082843 5200319475328460082843 Yes Department of Neurology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran