en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><b><span style="background:#2d7f8f"><span style="color:white">Background & Objective:</span></span><b> </b></b>Sepsis is a condition with various body responses and often results in death from infection. Serum lactate levels, elevated during hypoxia, stress, and critical illness, can serve as a sensitive yet non-specific indicator of metabolic stress. Hypoalbuminemia may be present in sepsis and exacerbate its severity. Researchers propose the lactate/albumin ratio (LAR) as a marker associated with multi-organ failure, and the SOFA score assesses mortality in critically ill patients. This study aims to investigate the correlation between lactate, albumin, LAR, and the SOFA score in septic patients.<br> <b><span style="background:#2d7f8f"><span style="color:white"><span style="letter-spacing:-.1pt">&nbsp;Materials & Methods:</span></span></span></b> <span style="letter-spacing:-.1pt">Thirty-five patients with sepsis were enrolled in this study. The LAR assessment and SOFA score were manually calculated; lactate and albumin levels were determined using a clinical chemistry analyzer. The Spearman test was employed to analyze the data, with a significance level of p < 0.05.</span><br> <b><span lang="EN-IN"><span style="background:#2d7f8f"><span style="color:white">Results: </span></span></span>&nbsp;</b><span style="letter-spacing:-.1pt">The median levels of lactate, albumin, and LAR were 5.50 (1.90&ndash;10.40) mmol/L, 2.40 (0.90&ndash;3.70) g/dL, and 2.29 (0.53&ndash;7.46), respectively. The results of the Spearman correlation test between albumin levels and the SOFA score showed no correlation (p = 0.643 and r = -0.081). Lactate, LAR, and the SOFA score showed a significant correlation (p = 0.002 and r = 0.498, p = 0.001 and r = 0.538).</span><br> <b><span style="background:#2d7f8f"><span style="color:white">Conclusion: </span></span>&nbsp;</b>There is a potential relationship between lactate, and LAR parameters and organ dysfunction severity.</span></span></p> Lactate, Albumin, LAR, SOFA Score 218 225 http://journal.zums.ac.ir/browse.php?a_code=A-10-7209-1&slc_lang=en&sid=1 Vera Oktaria Putri oktaria1986@gmail.com 5200319475328460084995 0009-0009-0314-1064 No Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia Ardhea Jaludamascena ardhea123@gmail.com 5200319475328460084996 0009-0003-6744-0553 No Department of Clinical Pathology, Dr. Kariadi Hospital, Semarang, Indonesia Dwi Retnoningrum dwiretno@fk.undip.ac.id 5200319475328460084997 5200319475328460084997 Yes Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia