en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><b><span style="background:#2d7f8f"><span style="color:white">Background & Objective:</span></span><b> </b></b><span style="color:black">Chronic kidney disease (CKD) is a major global health issue with increasing morbidity and mortality. Early stages are often asymptomatic, delaying diagnosis and treatment. This study aimed to evaluate the relationship between branched-chain amino acids (BCAAs) and catecholamine hormones-dopamine, epinephrine, and norepinephrine in CKD patients in Thi-Qar province, Iraq.</span><br> <b><span style="background:#2d7f8f"><span style="color:white"><span style="letter-spacing:-.1pt">&nbsp;Materials & Methods:</span></span></span></b> &nbsp;<span style="color:black"><span style="letter-spacing:-.1pt">This case-control study was conducted on 88 patients with CKD and 40 healthy controls. Blood samples were collected, and serum levels of BCAAs (valine, leucine, and isoleucine) and catecholamines were measured by ELISA method and relevant kits. Data were analyzed using SPSS version 11.5. The Mann-Whitney U test compared group means, and Spearman&rsquo;s rank correlation assessed associations between variables. Statistical significance was defined as <i>P</i><0.05.</span></span><br> <b><span lang="EN-IN"><span style="background:#2d7f8f"><span style="color:white">Results: </span></span></span>&nbsp;</b><span style="color:black"><span style="letter-spacing:-.1pt">BCAA concentrations were significantly lower in CKD patients compared with controls (35.53 &plusmn; 3.37 &mu;g/ml vs 61.06 &plusmn; 5.39 &mu;g/ml; <i>P</i><0.001). Catecholamine levels were also significantly reduced in CKD patients: dopamine (20.22 &plusmn; 8.18 pg/ml vs 48.80 &plusmn; 13.74 pg/ml), epinephrine (0.22 &plusmn; 0.072 pg/ml vs 0.48 &plusmn; 0.13 pg/ml), and norepinephrine (1.21 &plusmn; 0.23 pg/ml vs 2.31 &plusmn; 0.40 pg/ml) (all <i>P</i><0.001). Positive correlations were observed between BCAA and dopamine (r = 0.11), epinephrine (r = 0.22), and norepinephrine (r = 0.22).</span></span><br> <b><span style="background:#2d7f8f"><span style="color:white">Conclusion: </span></span>&nbsp;</b><span style="color:black">The findings indicate that decreased BCAA levels in chronic kidney disease (CKD) may contribute to impaired catecholamine synthesis. Monitoring these metabolic and neurochemical biomarkers could enhance disease assessment and management. Early nutritional interventions such as targeted amino acid supplementation may offer therapeutic benefits and merit further clinical investigation.</span></span></span></p> Catecholamines, Branched Chain Amino Acids, Chronic Kidney Disease 188 197 http://journal.zums.ac.ir/browse.php?a_code=A-10-7366-1&slc_lang=en&sid=1 Ali. H. Mohammed al.hu_ch@utq.edu.iq 5200319475328460087388 0003-0009-5787-7873 Yes Department of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, 64001, Iraq Mohammed. A. Aouda moh.ajah@sci.utq.edu.iq 5200319475328460087389 5200319475328460087389 No Department of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, 64001, Iraq Haider. M. Alyasiri Hayider.m.f@utq.edu.iq 5200319475328460087390 5200319475328460087390 No Department of Physiology, College of Medicine, University of Thi-Qar, Thi-Qar, 64001, Iraq