en Clinical Medicine Clinical Medicine گزارش موردی Case Report Article <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:12.0pt"><span style="line-height:107%">Background:</span></span></b><span style="font-size:12.0pt"><span style="line-height:107%"> ST-elevation myocardial infarction (STEMI) is a major cardiovascular emergency. Left ventricular ejection fraction (EF) is a critical predictor of prognosis post-STEMI. Diabetes mellitus (DM), especially newly diagnosed, may influence cardiac function.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:12.0pt"><span style="line-height:107%">Methods:</span></span></b><span style="font-size:12.0pt"><span style="line-height:107%"> This cross-sectional study included 283 patients admitted with STEMI. Demographic, clinical, laboratory data, angiographic data, and EF were collected. DM was screened with HbA1C, and EF was evaluated by transthoracic 2D echocardiography. Statistical analyses were performed by SPSS 26.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:12.0pt"><span style="line-height:107%">Results:</span></span></b><span style="font-size:12.0pt"><span style="line-height:107%"> Among 1562 patients following refer with acute coronary syndrome (ACS), 283 patients with STEMI and without exclusion criteria were entered to present study. Mean age was <span style="color:black">63.1 &plusmn; 10.5years. &nbsp;The patients with reduced EF </span>were significantly older <span style="color:black">(61.4 &plusmn; 9.8 years vs 67.2 &plusmn; 10.8 years; </span></span></span><span style="font-size:12.0pt"><span style="line-height:107%"><span style="color:black">P-value</span></span></span><span style="font-size:12.0pt"><span style="line-height:107%"><span style="color:black"><0.001</span></span></span><span style="font-size:12.0pt"><span style="line-height:107%"><span style="color:black">).</span></span></span><span style="font-size:12.0pt"><span style="line-height:107%"> A statistically significant association was found between new diagnosed DM and reduced EF (</span></span><span style="font-size:12.0pt"><span style="line-height:107%"><span style="color:black">P-value=0.037</span></span></span><span style="font-size:12.0pt"><span style="line-height:107%">). Smoking was also significantly associated with reduced EF (</span></span><span style="font-size:12.0pt"><span style="line-height:107%"><span style="color:black">P-value=0.023</span></span></span><span style="font-size:12.0pt"><span style="line-height:107%">). No significant association was found between EF and body mass index (BMI), sex, hypertension (HTN), dyslipidemia (DLP), coronary artery disease (CAD) severity, culprit lesion, and MI territory, .</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:107%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:12.0pt"><span style="line-height:107%">Conclusion:</span></span></b><span style="font-size:12.0pt"><span style="line-height:107%"> New DM, older age, and smoking are significantly associated with reduced EF in patients with STEMI.</span></span></span></span></span></span></span><br> &nbsp; Keywords: ST-segment elevation myocardial infarction, ejection fraction, Diabetes mellitus 41 41 http://journal.zums.ac.ir/browse.php?a_code=A-10-7089-1&slc_lang=en&sid=1 Effat Partovinezhad Epartovinezhad@zums.ac.ir 5200319475328460090353 5200319475328460090353 No Zanjan University of Medical Sciences, Zanjan, Iran. Hamid Khederlou dr.khederlou@gmail.com 5200319475328460090357 5200319475328460090357 Yes Cardiology Department, Zanjan University of Medical Sciences, Zanjan, Iran. Mohammad Mohsenpour Sisi mhmmmd1997@gmail.com 5200319475328460090354 5200319475328460090354 No Zanjan University of Medical Sciences, Zanjan, Iran. Narges Mohammadi narges.mdi1994@gmail.com 5200319475328460090355 5200319475328460090355 No Zanjan University of Medical Sciences, Zanjan, Iran. Mobina Ghajar Mobinaghajar9078@gmail.com 5200319475328460090356 5200319475328460090356 No Zanjan University of Medical Sciences, Zanjan, Iran.