en Life Science Life Science مقاله پژوهشی Original Research Article <span style="font-size:16px;"><span style="font-family:Times New Roman;"><span new="" roman="" times=""><b><span style="background:#2d7f8f"><span style="color:white">Background & Objective:</span></span></b><b> </b><b>&nbsp;</b><span style="color:black">Schiff bases are widely recognized for their diverse biological activities, particularly their antibacterial properties. These compounds hold the potential to enhance the therapeutic efficacy of existing bactericidal drugs, such as sulfamethoxazole, as validated through in silico molecular docking and in vitro antibacterial assays.</span></span><br> <span new="" roman="" times=""><b><span style="background:#2d7f8f"><span style="color:white"><span style="letter-spacing:-.1pt">&nbsp;Materials & Methods:</span></span></span></b> &nbsp;<span style="color:black"><span style="letter-spacing:-.1pt">This research aimed to synthesize novel Schiff base derivatives of sulfamethoxazole and investigate their antibacterial efficacy. The derivatives were synthesized via the condensation of sulfamethoxazole with four substituted benzaldehydes: 4-chloro, 4-hydroxy, 4-bromo, and 4,4-dimethylbenzaldehyde. The resulting compounds were characterized using melting point determination, FT-IR, and H NMR spectroscopy.</span></span></span><br> <span new="" roman="" times=""><b><span lang="EN-IN"><span style="background:#2d7f8f"><span style="color:white">Results: </span></span></span></b><b>&nbsp;</b><span style="color:black"><span style="letter-spacing:-.1pt">Compounds <b>3</b> and <b>4</b> especially showed extremely high docking scores and significant antibacterial inhibitory zones, surpassing the combined medication. Conclusion:&nbsp; Laboratory research demonstrated the capacity to reverse bacterial resistance processes upon inspection and the potential for antibacterial chemicals to address the existing resistance problem in the future.</span></span></span><br> <span new="" roman="" times=""><b><span style="background:#2d7f8f"><span style="color:white">Conclusion: </span></span></b><b>&nbsp;</b><span style="color:black">Laboratory research demonstrated the capacity to reverse bacterial resistance processes upon inspection and the potential for antibacterial chemicals to address the existing resistance problem in the future.</span></span><br> &nbsp;</span></span> Sulfamethoxazole, Schiff base, antibacterial activity. 184 192 http://journal.zums.ac.ir/browse.php?a_code=A-10-7462-1&slc_lang=en&sid=1 Zahraa M. Abdulmohsan zahraa.m.abdulmohsan@aliraqia.edu.iq 5200319475328460090101 5200319475328460090101 Yes College of Medicine, AL-Iraqia University, Baghdad, Iraq Akram S. Karamallah akram.s.karamallah@uotechnology.edu.iq 5200319475328460090102 5200319475328460090102 No Electromechanical Engineering Department, University of Technology, Baghdad-Iraq, Andy N. S. Shamaya andy.n@sc.uobaghdad.edu.iq 5200319475328460090103 0009-0002-2101-7955 No Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq,