en Medical Biology Medical Biology مقاله مروری Review Article <div style="text-align: justify;"><span style="line-height:2;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="unicode-bidi:embed">Spinal cord injury (SCI) causes irreversible neuronal loss, disruption of neural circuits, and persistent neurological deficits, while the limited regenerative capacity of the adult central nervous system remains a major barrier to recovery. This review examines the role of epigenetic regulation in neural repair after SCI and highlights its therapeutic potential. We summarize evidence on major epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, as well as their interactions with Wnt/&beta;-catenin signaling and Polycomb group proteins in regulating neural stem/progenitor cell fate, neuronal differentiation, and axonal regeneration. We further discuss epigenetic therapeutic strategies, particularly histone deacetylase inhibition with valproic acid, in combination with neural stem/progenitor cell transplantation. Emerging approaches involving induced pluripotent stem cell-derived neural progenitors and direct cellular reprogramming are also considered. Collectively, current evidence suggests that integrating epigenetic modulation with stem cell-based and cellular reprogramming strategies may enhance neural regeneration and functional recovery after SCI and represents a promising direction for future translational research.</span></span></span></span><br> &nbsp;</div> epigenetics, spinal cord injury, neural stem cells, neural precursor cells, histone modifications, non-coding RNAs, regenerative medicine 57 57 http://journal.zums.ac.ir/browse.php?a_code=A-10-2058-6&slc_lang=en&sid=1 Negar Abdanipour abdanipour@zums.ac.ir 5200319475328460092229 5200319475328460092229 No Department of Pediatric, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran Alireza Abdanipour abdani.anatomy@yahoo.com 5200319475328460092230 5200319475328460092230 No Department of Anatomy, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran Hadi Feizi hfeizik@zums.ac.ir 5200319475328460092231 5200319475328460092231 Yes Department of Physiology, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran