fa بررسی رابطه‌ی نوع اسیدهای چرب فسفولیپیدهای جدار لیپوپروتئین با چگالی بالا با شدت درگیری عروق کرونر پس از آنژیوگرافی مقاله پژوهشی Original Research Article <p>Background and Objective: The phospholipids fatty acid content of high density lipoprotein (HDL) has recently been found to be related to several important biological functions which may serve as a risk factor for coronary artery disease (CAD). The purpose of this study was to investigate whether fatty acid composition of HDL phospholipids correlates with the presence and severity of coronary artery disease. Materials and Methods: The study population included 117 patients with coronary artery disease which was approved by angiography. The severity of CAD was assessed by the number of arteries (1, 2 or 3) with more than 50% stenosis reported by angiography. The fatty acid composition of HDL phospholipids was determined by gas liquid chromatography. The independence of association between fatty acids and CAD were evaluated by multivariate analyses which included all of the variables associated with the severity of CAD in univariate analysis. Results: These analyses showed that the association of EPA (&beta;= 0.23, P<0.01) and DHA (&beta;= 0.17, P<0.05) with the severity of CAD was inversely and independently significant. Conclusion: Some kinds of polyunsaturated HDL fatty acid contents such as EPA and DHA (omega-3 fatty acids) have adverse association with severity of CAD. Key words: Coronary artery disease, Fatty acids, High-density lipoprotein</p> Key words: Coronary artery disease, Fatty acids, High-density lipoprotein 13 22 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-465&slc_lang=fa&sid=1 Mohammad Nouri محمد نوری 5200319475328460060571 5200319475328460060571 No Dept. of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Masoud Darabi مسعود دارابی mdarabi@hotmail.com 5200319475328460060572 5200319475328460060572 Yes Dept. of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Ali Rahimipour علی رحیمی پور 5200319475328460060573 5200319475328460060573 No Dept. of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Mohammad Rahbani محمد رهبانی 5200319475328460060574 5200319475328460060574 No Dept. of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Naser Aslanabadi ناصر اصلان آبادی 5200319475328460060575 5200319475328460060575 No Dept. of Cardiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Maghsoud Skaaker مقصود شاکر 5200319475328460060576 5200319475328460060576 No Dept. of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Amir Mehdizadeh امیر مهدی ‍اده 5200319475328460060577 5200319475328460060577 No Dept. of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran