fa بررسی اثرات هگزامتیلن‌تتراآمین بر تعداد ماست‌سل‌های موجود در لایه‌ی احشایی پرده‌ی جنب ریه‌ی موش‌های صحرایی آلوده به سولفور- موستارد مقاله پژوهشی Original Research Article <p>Background and Objective: Sulfur mustard is a potent chemical vesicant warfare agent that remains a significant military and civilian threat. Inhalation of sulfur mustard gas causes inflammation and injury to airways and bronchioles. Mast cells promote allergic reactions when exposed to some chemical compounds such as HD. Hexamethylenetetramine has been shown to protect human lung cells against HD toxicity and has also been shown to be effective against the chemical warfare agent phosgene in vivo. The aim of this study was to evaluate the effects of HMT on the number of mast cells in the lamina propria of visceral layer of pleura in male rats after exposure to sulfur mustard. Materials and Methods: Twenty seven Albino Wister male rats weighting 200&plusmn;20 gr were randomly divided into 5 groups (Normal Saline (N.S), HMT, HD, Pre-exposure and Post-exposure). HD, Pre-exposure and Post-exposure groups received sulfur-mustard and N.S group received Normal Saline as a solvent by intratracheal catheter. HMT, Pre-exp and Post-exp groups received HMT via intra-peritoneal for 14 days. After the day 14, body weight changes, the rate of lung tissue injury and the number of mast cells measured in the pleura&#39;s visceral layer of the rats&#39; lungs. Results: Histological examination and mast cells count showed no significant difference when compared among NS, HMT, Pre-exposure and Post-exposure groups. However, significant reduction was seen in the number of mast cells in HMT and NS groups in comparison with the HD group (p < 0/001). The number of mast cells in the Pre-exposure and Post-exposure groups was also significantly lower than that of the HD group (p < 0/001). Conclusions: From the results of this study it can be concluded that HMT may have a positive protective and therapeutic effect on lung tissue in rats. Key words: Sulfur mustard, Lung, Mast cell, Hexamethylenetetramine, Rat</p> Key words: Sulfur mustard, Lung, Mast cell, Hexamethylenetetramine, Rat 31 40 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-467&slc_lang=fa&sid=1 Zahra Abdi زهرا عبدی 5200319475328460060582 5200319475328460060582 No Emam Hosien Hospital, Zanjan, Iran Seyed hamoon Sadraie سید همایون صدرایی h_sadraie@yahoo.com 5200319475328460060583 5200319475328460060583 Yes Dept. of Anatomy, Baghiyatallah University of Medical Sciences, Tehran, Iran GHolam Reza Kaka غلامرضا کاکا 5200319475328460060584 5200319475328460060584 No Dept. of Anatomy, Baghiyatallah University of Medical Sciences, Tehran, Iran Mahvash Jafari مهوش جعفری 5200319475328460060585 5200319475328460060585 No Dept. of Biochemistery, Faculty of Medicine, Baghiyatallah University of Medical sciences, Tehran, Iran Mehdi Saberi مهدی صابری 5200319475328460060586 5200319475328460060586 No Dept. of pharmacology, Faculty of Medicine, Baghiyatallah University of Medical sciences, Tehran, Iran Mohammad Hasan Hossini Akbari محمد حسن حسینی اکبری 5200319475328460060587 5200319475328460060587 No Baghiyatallah Hospital, Baghiyatallah University of Medical Sciences, Tehran, Iran Hosein Dashtnavard حسین دشت نورد 5200319475328460060588 5200319475328460060588 No Dept. of Anatomy, Baghiyatallah University of Medical Sciences, Tehran, Iran Ali Pandoeh علی پندوه 5200319475328460060589 5200319475328460060589 No Dept. of Immunology, Baghiyatallah University of Medical Sciences, Tehran, Iran