Journal of Advances in Medical and Biomedical Research

fa بررسی تداخل اثر بی دردی حاصل از JWH133 و دوزهای معمول و بسیار ناچیز سلکوکسیب در موش سوری Interaction between JWH133-induced Antinociception and two extreme Doses of Celecoxib مقاله پژوهشی Original Research Article <p>Background and Objective: JWH133 is known to have cannabinoid-2 (CB2) receptor agonist properties. Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is also known to have antinociceptive properties. Endocannabinoids produce analgesia possibly through cyclooxygenase (COX) pathway. The aim of the present work was: to study the effect of celecoxib on JWH133 induced antinociception and to compare the effects of two different dose ranges of celecoxib (mg/kg and nano g/kg) on the JWH133 antiniciceptive effect. Materials and Methods: We have studied the possible interaction of administration of mg/kg (50-200 mg/kg) and Ultra-Low Dose (ULD) (25 and 50 ng/kg) of celecoxib on the antinociceptive effect of intraperitoneal (i.p.) injection of JWH133 using formalin test in mice. Results: JWH133 (0.01, 0.1 and 1 mg/kg) induced antinociceptive effect just in phase I of the formalin test. Celecoxib (50-200 mg/kg) and its ULD (25 and 50 ng/kg) attenuated and potentiated, JWH133 induced antinociception, respectively. Conclusions: It is concluded that JWH-133 induced antinociception is modulated by celecoxib and mg/kg doses of celecoxib showed opposite effects compare to its ultra-low doses.</p> Key words: JWH133, Antinociception, Celecoxib, Ultra-Low Dose (ULD), Mice 11 22 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-486&slc_lang=fa&sid=1 Zahra Ghahremani زهرا قهرمانی 5200319475328460060478 5200319475328460060478 No Dept. of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. Soudeh Rezaee- Kalaj سوده رضائی کلج 5200319475328460060479 5200319475328460060479 No Dept. of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. Mohammad Reza Zarrindast محمد رضا زرین دست 5200319475328460060480 5200319475328460060480 No Dept. of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Bizhan Jahanguiri بیژن جهانگیری 5200319475328460060481 5200319475328460060481 No Dept. of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Reza jafari محمد رضا جعفری jafarimrj@yahoo.com 5200319475328460060482 5200319475328460060482 Yes Dept. of Physiology and Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.