en Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article <p style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Background and Objective:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="line-height:150%"><span style="background:white">Oral cancer is one of the 10 most common cancers in the world and its global outbreak is increasing. Saliva assessment is one of the non-invasive diagnostic methods for this cancer. The aim of the study was to&nbsp;achieve&nbsp;a comprehensive conclusion about changes in salivary antioxidants in patients with squamous cell carcinoma of the mouth (OSCC).</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="line-height:150%"><span style="background:white">In the present study, as a systematic review and meta-analysis study, information&nbsp;extracted&nbsp;by searching in external databases (PubMed, Science Direct, Scopus, Web of Science, google scholar) and internal databases (IranMedex, Scientific Information Database,&nbsp;Magiran)&nbsp;between the years 1980 to 2020. Comprehensive meta-analysis version 2 software was used to analyze the data (P <0.05).</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></strong>&nbsp;<span style="line-height:150%"><span style="line-height:150%"><span style="background:white">Of 497 articles, 271 duplicate articles were deleted,&nbsp;and then, after reviewing the titles and abstracts of the articles, another 197 articles&nbsp;were removed. The full text of 26 articles&nbsp;were reviewed&nbsp;and evaluated. Finally, based on the&nbsp;STROB&nbsp;checklist, the data of 10 articles&nbsp;were entered&nbsp;into the meta-analysis. Salivary&nbsp;malondialdehyde&nbsp;(MDA) index levels were much higher in patients with&nbsp;OSCC&nbsp;than in healthy people (P=0.0001).</span> <span style="background:white">All salivary antioxidant indexes (TAC) (P=0.003) and GSH glutathione (P=0.008) saliva was significantly lower in patients than in the healthy group and regarding the salivary superoxide dismutase (SOD) index was no significant.</span></span></span><br> <strong new="" roman="" style="font-family: " times=""><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusion:</span></span>&nbsp;</strong><span style="line-height:150%"><span style="line-height:150%">In general, antioxidant supplements&nbsp;may&nbsp;be able to help prevent, treat, and improve the prognosis of this disease, which requires further research in this area.</span></span></span></span></p> Squamous cell carcinoma of the mouth, Antioxidant, Saliva 471 476 http://journal.zums.ac.ir/browse.php?a_code=A-10-4795-3&slc_lang=en&sid=1 Forooz Keshani f_keshani@dnt.mui.ac.ir 5200319475328460088911 5200319475328460088911 No Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Sara Rashed sara.rashed2711@gmail.com 5200319475328460088912 5200319475328460088912 No Students Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Mohammad Javad Tarahi mj.tarrahi@gmail.com 5200319475328460088913 5200319475328460088913 No Dept. of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran Laleh Maleki l.maleki@dnt.mui.ac.ir 5200319475328460088914 5200319475328460088914 Yes Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran