Journal of Advances in Medical and Biomedical Research

en Correlation of PSA Levels with Inflammatory and Hematological Biomarkers for Differential Diagnosis of Prostate Cancer and Benign Prostatic Hyperplasia Clinical Medicine Clinical Medicine مقاله پژوهشی Original Research Article Background: Differentiating Prostate Cancer (PC) from benign prostatic hyperplasia (BPH) remains clinically challenging due to overlapping symptoms and biomarker alterations. This study compared biochemical, hematological, and inflammatory markers in both conditions to assess their potential diagnostic value. Methods: A cross-sectional study was performed on 40 patients with PC and 120 patients with benign prostatic hyperplasia. The measurement of biochemical parameters included complete blood count, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) and total and free prostate-specific antigen (PSA). The process involved statistical comparisons, ROC analysis, and correlation tests Results: Compared to BPH, patients with PC had significantly higher PSA (free and total), CRP, and lymphocyte counts (All p<0.05). Despite the diagnostic utility of PSA and inflammatory markers (AUCs 0.68-0.80), hematological parameters in isolation were not strong discriminators (AUCs<0.50), and a combined biomarker strategy would be more effective in clinical discrimination. Conclusion: Detection of PC from BPH is accurately achieved by examining elevated free and total PSA levels, along with increased systemic inflammation, as indicated by CRP. The independent discriminant value of hematologic parameters is limited despite significant diversity between groups.. A combination of PSA and inflammatory markers in a two-biomarker strategy can improve clinical discrimination and reduce inappropriate therapy.   PSA, BPH, prostate cancer, CRP, ESR, NLR, PLR 8 8 http://journal.zums.ac.ir/browse.php?a_code=A-10-5630-2&slc_lang=en&sid=1 Hayder Ahmed Sahar Algburi hayder1261998@gmail.com 5200319475328460088367 5200319475328460088367 No 1Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Ahmad Deylami 5200319475328460088368 5200319475328460088368 No Department of Urology, School of Medicine, Mazandaran University of Medical Sciences Hadis Musavi 5200319475328460088369 5200319475328460088369 No Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Hossein Mokhtari 5200319475328460088370 5200319475328460088370 No 3Amol faculty of paramedicine, Mazandaran university of medical sciences, Sari, Iran Neda Masoumi Qajari 5200319475328460088371 5200319475328460088371 No Genetic biology,Tonekabon Islamic Azad University,Tnekabon,Iran Fatemeh Lotfi Asrami 5200319475328460088372 5200319475328460088372 No 5Department of Biochemistry, Biophysics, Genetics and Nutrition, School of Medicine Metabolic Disorders Research Center, Golestan University of Medical Sciences Abbas Khonakdar 5200319475328460088373 5200319475328460088373 Yes Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran