دوره 33، شماره 157 - ( 1-1404 )                   جلد 33 شماره 157 صفحات 100-95 | برگشت به فهرست نسخه ها

Ethics code: IR.UMA.REC.1402.091

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Khodayi Zavyah O, Bolboli L, Siahkohian M, Baghaiee B. Effect of 8 Weeks of High-intensity Interval Training (HIIT) Combined with L-cysteine Supplementation on the Level of TLR4 Protein and TNF-α in the Heart Tissue of Rats with Type 2 Diabetes. J Adv Med Biomed Res 2025; 33 (157) :95-100
URL: http://journal.zums.ac.ir/article-1-7513-fa.html
Effect of 8 Weeks of High-intensity Interval Training (HIIT) Combined with L-cysteine Supplementation on the Level of TLR4 Protein and TNF-α in the Heart Tissue of Rats with Type 2 Diabetes. Journal of Advances in Medical and Biomedical Research. 1404; 33 (157) :95-100

URL: http://journal.zums.ac.ir/article-1-7513-fa.html

Effect of 8 Weeks of High-intensity Interval Training (HIIT) Combined with L-cysteine Supplementation on the Level of TLR4 Protein and TNF-α in the Heart Tissue of Rats with Type 2 Diabetes
چکیده:   (117 مشاهده)

Background and Objective: Cardiovascular complications linked to diabetes are among the most severe manifestations of the disease. This study evaluated how an 8-week regimen of high-intensity interval training (HIIT) combined with L-cysteine supplementation influences TLR4 protein expression and TNF-α levels in the cardiac tissue of rats with type 2 diabetes.
Methods: In this experimental study, random sampling divided nine male Wistar rats into five control and experimental groups. After inducing diabetes in experimental and diabetic control groups, the exercise group performed high-intensity interval training for eight weeks. One-way analysis of variance and Bonferroni post hoc test were used to determine the difference between groups.
Results: Type 2 diabetes in rats is associated with a significant increase in the TLR4 and TNF-α levels in heart tissue (p=0.001). Performing HIIT can reduce the TLR4 index to the pre-diabetic condition (p=0.001). Also, performing HIIT with an L-cysteine supplement is associated with a significant decrease in TLR4 and TNF-α levels (p=0.001).
Conclusion: High-intensity interval training (HIIT) in type 2 diabetic rats triggers a significant suppression of the TLR4 signaling pathway in cardiac tissue, possibly contributing to reduced inflammation and improved insulin resistance.

     
نوع مطالعه: مقاله پژوهشی | موضوع مقاله: Health Improvement Strategies
دریافت: 1403/10/14 | پذیرش: 1404/1/31 | انتشار: 1404/3/8
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