دوره 33، شماره 157 - ( 1-1404 )
جلد 33 شماره 157 صفحات 165-159 |
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Ethics code: IR.MUQ.AEC.1401.031
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Moslehi A, Komeili Movahhed T, Heidari F. Protective Effect of Chlorogenic Acid on ER-stress and Oxidative Stress Crosstalk in Mice. J Adv Med Biomed Res 2025; 33 (157) :159-165
URL: http://journal.zums.ac.ir/article-1-7633-fa.html
URL: http://journal.zums.ac.ir/article-1-7633-fa.html
Protective Effect of Chlorogenic Acid on ER-stress and Oxidative Stress Crosstalk in Mice. Journal of Advances in Medical and Biomedical Research. 1404; 33 (157) :159-165
چکیده: (33 مشاهده)
Background and Aims: Cross-talk between endoplasmic reticulum (ER) stress and oxidative stress has been recognized as contributing to several pathological conditions, particularly those affecting the respiratory system. This study aims to investigate the potential protective role of chlorogenic acid (CA) against oxidative stress in a murine model of ER stress induced by tunicamycin.
Material and Methods: Mice were divided into six groups: a control group (saline), a vehicle group (DMSO), a CA group, a tunicamycin group, a CA + tunicamycin group, and a CA + tunicamycin group (both with a 20 mg/kg CA dose). After 72 hours of treatment, protein levels were investigated by ELISA, mRNA levels by RT-PCR, and histopathological alterations were examined by H&E staining.
Results: We found that 20 mg/kg CA alleviated GRP78 mRNA levels, decreased MDA, and increased GSH levels. It also showed potent anti-inflammatory and anti-fibrotic effects in the lungs of ER-stress induced mice.
Conclusion: CA administration decreased oxidative stress markers by alleviating ER stress. This indicates a mechanistic link between ER stress and oxidative stress.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Pharmacology
دریافت: 1403/11/24 | پذیرش: 1404/2/25 | انتشار: 1404/3/8
دریافت: 1403/11/24 | پذیرش: 1404/2/25 | انتشار: 1404/3/8
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