fa بررسی اثر عصاره‌ی چای سبز بر سطح سرمی آدیپونکتین و وضعیت مقاومت به انسولین در بیماران مبتلا به دیابت نوع دو مقاله پژوهشی Original Research Article <p>Background and Objective: Adiponectin is a novel adipose tissue-specific adipokine that can increase insulin sensitivity. Many studies have shown anti obesity and anti diabetic effects of green tea consumption. In this study we examined the effects of green tea extract on circulating adiponectin levels and insulin resistance status in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: In this double blind randomized clinical trial 58 type 2 diabetic patients with BMI &ge; 25 were recruited from an unselected population from the outpatient clinic of Shariati Hospital, Tehran, Iran. Patients were randomly divided into two groups green tea extract and placebo. All the patients received the capsules for 8 weeks. Laboratory measurements including fasting serum adiponectin, insulin, HOMA-IR, FPG, OGTT, HbA1c and lipid profile and anthropometric were performed before and after the intervention. Nutrient intakes were obtained via 24- hour recall from each patient in three successive days. The data were analyzed using appropriate software. Results: We found a significant effect of green tea extract on increasing the logarithm of serum adiponectin in diabetic patients (0.15&plusmn;0.10 &micro;g/ ml, P < 0.05). A significant independent correlation between the logarithm of serum adiponectin and WHR (Waist to Hip Ratio) was found (P= 0.009, t= -2.7). The consumption of green tea extract had a significant effect in control the levels of HbA1C, weigh and also BMI in green tea group (P < 0.05). Conclusion: The results showed that consumption of green tea extract can be useful in the control of T2DM by increasing the levels of serum adiponectin and controlling the weight, BMI and HbA1C levels in patients with T2DM.</p> Key words: Adiponectin, Green tea extract, T2DM. 44 57 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-519&slc_lang=fa&sid=1 Somaieh Mohammadi سمیه محمدی 5200319475328460060351 5200319475328460060351 No Dept. of Nutrition and Biochemistry, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Jafar Hasseinzadeh Attar محمدجواد حسین زاده Hosseinzadeh.md.phd@gmail.com 5200319475328460060352 5200319475328460060352 Yes Dept. of Nutrition and Biochemistry, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran. Mehrdad Karimi مهرداد کریمی 5200319475328460060353 5200319475328460060353 No Dept. of Traditional Medicine, School of medicine. Tehran University of Medical Sciences, Tehran, Iran Arash Hossainnezhad آرش حسین نژاد 5200319475328460060354 5200319475328460060354 No Endocrine and Metabolic Research Center, Shariati Hospital. Tehran University of Medical Sciences, Tehran, Iran Mohammad Reza Eshraghian محمدرضا اشراقیان 5200319475328460060355 5200319475328460060355 No Dept of Statistics, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran Seyed Hosein Hosseini سید حسین حسینی 5200319475328460060356 5200319475328460060356 No School of Pharmacology, Islamic Azad University of Medical Sciences, Tehran, Iran Mazaher Rahmani مظاهر رحمانی 5200319475328460060357 5200319475328460060357 No Endocrine and Metabolic Research Center, Shariati Hospital. Tehran University of Medical Sciences, Tehran, Iran Arezo Karimi آرزو کریمی 5200319475328460060358 5200319475328460060358 No Endocrine and Metabolic Research Center, Shariati Hospital. Tehran University of Medical Sciences, Tehran, Iran Nazila Jafari نازیلا جعفری 5200319475328460060359 5200319475328460060359 No Fayazbakhsh Hospital, Social Security Organization, Tehran, Iran.