fa مقایسه‌ی میزان کاهش مقادیر حداکثرحجم بازدمی در ثانیه‌ی اول ( (FEV1و حداکثر جریان بازدمی (PEF) در گونه‌ی سرفه‌ای آسم (Cough Variant Asthma) در جریان تست متاکولین مقاله پژوهشی Original Research Article <p style="text-align: justify;"><strong><em>Background and Objective:</em></strong> Asthma is one of the most common chronic diseases with an increasing prevalence. The cough variant of asthma (CVA) is a latent form of the disease. The aim of this study is to compare the decreasing rates of FEV1 and PEF during the methacholine challenge test.<br> <strong><em>Materials and Methods:</em></strong> In this study, we tested a total of 120 patients (14-65 years old), whom were referred to the respiratory clinic with complaints of chronic cough, using normal chest and sinus x-ray and spirometry. Also other causes of chronic cough were rulled out. Spirometry and Peak Flowmetry were done during the methacholine challenge test, then FEV1 and PEF were recorded.<br> <strong><em>Results:</em></strong> From 120 patients, 47 patients (39.2%) were male and 73 (60.8%) were female. Thirty three (27.5%) patients<a name="OLE_LINK4"></a><a name="OLE_LINK3"> showed a </a>&ge; 20% decrease in FEV1, while 35 patients (29.2%) had a &ge; 20% decrease in PEFp. Decreasing values of FEV1 and PEFp with r=0.49 and <em>P</em>-value<0.0001 were significant. Normalization for age, sex, and occupation shows that these factors have no effects on the decrease observed for FEV1 and PEFp.<br> <strong><em>Conclusion:</em></strong> Based on the correlation ratio for PEFp in comparison with spirometry&rsquo;s FEV1, we suggest using peak flowmetry instead of spirometry for diagnosing CVA. According on the ROC_curve, we recommend a &ge; 15.5% decrease in the level of PEFp with 79% sensitivity and 69% specificity.</p> Asthma, CVA, FEV1, PEF, Methacholine 22 30 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-602&slc_lang=fa&sid=1 Samad Ghodrati صمد قدرتی 5200319475328460060037 5200319475328460060037 No Dept. of Internal Medicin, Vali-e-asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Ahmad Hormati احمد حرمتی hormatia@yahoo.com 5200319475328460060038 5200319475328460060038 Yes Dept. of Internal Medicine,Vali-e-asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Seyed Nourdin Mousavinasab سید نورالدین موسوی نسب 5200319475328460060039 5200319475328460060039 No Dept. of Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Mahboubeh Afifian محبوبه عفیفیان 5200319475328460060040 5200319475328460060040 No Tehran University of Medical Sciences, Tehran, Iran