fa بررسی سطح سرمی B-HCG در درجات متفاوت سرطان پستان و میزان تغییر آن به دنبال شیمی درمانی طی سال‌های 89-1388 در استان زنجان کارآزمایی بالینی Clinical Trials <p>Background and Objective: Elevation of the b-HCG serum levels has been reported in several tumors including breast cancer, and it is usually associated with aggressiveness. The aim of this study was to examine the possible correlation between the b-HCG serum levels and different grades of breast cancer tumors in patients undergoing chemotherapy. Materials and Methods: This cross-sectional study was conducted in the city of Zanjan during 2009-10. Serum samples from 56 cases of breast cancer patients were collected after surgery and prior to chemotherapy for analysis of total free b-HCG by electro chemiluminescence immunoassay, and the same procedure was repeated after 8 courses of chemotherapy. The b-HCG serum levels were compared in poor versus mild to moderate grades before and after chemotherapy. Results: In 37 cases of mild to moderate grade tumors, the mean b-HCG level was 1.09 &plusmn;1.4 miu/ml compared with 1.2 &plusmn;0.3 miu/ml (P= 0.75) in 29 cases of poor grade tumors. The mean b-HCG levels before and after chemotherapy were 1.15 &plusmn;1.4 miu/ml and 1.17 &plusmn;1.4 miu/ml (P=0.24), respectively. Conclusion: We did not find any significant association between the b-HCG serum levels and breast cancer tumor grades. Furthermore, chemotherapy does not appear to have an effect on b-HCG serum levels.</p> Keywords: Serum -HCG, Breast cancer, Cellular grade, Chemotherapy 55 63 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-654&slc_lang=fa&sid=1 Reza Eghdam Zamiri رضا اقدام ضمیری 5200319475328460059811 5200319475328460059811 No Dept. of Oncology, Zanjan University of Medical Sciences, Zanjan, Iran. Minoosh Moghimi مینوش مقیمی 5200319475328460059812 5200319475328460059812 No School of Medicine, Dept. of Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. Nouradin Mosavi Nasab نورالدین موسوی نسب 5200319475328460059813 5200319475328460059813 No School of Medicine, Dept. of Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. Hamidreza Amirmoghadami حمید‌رضا امیر مقدمی 5200319475328460059814 5200319475328460059814 No Vali-e-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran. Maryam Joghatae مریم جغتایی mjoghatae55@gmail.com 5200319475328460059815 5200319475328460059815 Yes Dept. of Oncology, Zanjan University of Medical Sciences, Zanjan, Iran. Abdolamir Feizi عبدالامیر فیضی 5200319475328460059816 5200319475328460059816 No Vali-e-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.