fa بررسی اثر عصاره‌ی هیدروالکلی برگ گیاه گلپر روی تشنج ناشی از تزریق پنتیلن تترازول بر روی موش سوری کارآزمایی بالینی Clinical Trials <p>Background and Objective: Epilepsy is the most common neurological disorder after stroke. The aim of the present study was to evaluate the effect of hydroalcoholic extract of Heracleum persicum on pentylenetetrazol (PTZ) - induced seizure in mice. Materials and Methods: In this study, 30 male mice were divided into five groups. 30 minutes after IP administration with different doses of extract (75,150, 300, 600mg/kg), PTZ (80 mg/kg) was injected to animals and they were instantly transferred to a special cage. Consequently, the convulsive behaviors of the mice were recorded by a camera as long as 20 minutes and the data were converted into seconds to be considered for analysis. Results: The results indicated that hydroalcoholic extract of Heracleum persicum has a significant effect on threshold tonic seizure in doses of 150 mg/kg, 300mg/kg and 600 mg/kg. In clonic phase, threshold increased slightly with an increase in doses of extract. In tonic-clonic phase, threshold increase was significant only in doses of 150 mg/kg and 900 mg/kg. This extract significantly decreased seizure duration time both in tonic and tonic-clonic phases upon dose increasing. Conclusion: The results of the present study imply that injection of hydro-alcoholic extracts of Heracleum persicum led to anticonvulsant activity. This extract augmented the onset of different seizure phases while reduced duration of tonic and tonic-clonic phases.</p> Keywords: Heracleum persicum, Anticonvulsant activity, Pentylenetetrazol, Seizure, Mice 45 55 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-712&slc_lang=fa&sid=1 Fatemeh Saeidi فاطمه سعیدی 5200319475328460059556 5200319475328460059556 No Cellular and Molecular Research Center, Dept. of Physiology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Hasan Azhdari Zarmehri حسن اژدری زرمهری hasan.azhdari@gmail.com 5200319475328460059557 5200319475328460059557 Yes Cellular and Molecular Research Center, Dept. of Physiology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Elaheh Erami الهه ارمی 5200319475328460059558 5200319475328460059558 No Cellular and Molecular Research Center, Dept. of Physiology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Benyamin Alimohammadi بنیامین علی محمدی 5200319475328460059559 5200319475328460059559 No Torbat-e-Heydarieh University of Medical Sciences, Torbat-e-Heydarieh, Iran