fa تأثیر استفاده از مکمل ویتامین E بر وضعیت متابولیک و سطح سرمی لیپوپروتئین a در بیماران دیابتی نوع 2 کارآزمایی بالینی Clinical Trials <p>Background and Objective: Type 2 diabetes represents an independent risk factor for cardiovascular diseases. The aim of the present study was to investigate the effects of vitamin E supplementation on metabolic status and serum lipoprotein (a) level in type 2 diabetic patients. Materials and Methods: In this randomized double-blind, controlled clinical trial 83 type 2 diabetic patients (men and woman) were assigned into two groups as the intervention and control groups. The intervention group (n=42) took 400 IU vitamin E per day and the control group (n=41) received placebo for 8 weeks. Anthropometric measurements, dietary intake data and fasting blood samples were obtained from each patient before and after the end of study. Results: Serum vitamin E and lipid-standardized &alpha;-tocopherol significantly increased after vitamin E supplementation in the intervention group (P=0.0001). A significant decrease in fasting blood glucose was observed in the vitamin E group compared with the placebo group at the end of the study (P=0.027). Alterations in body mass index, dietary intakes, levels of lipoprotein (a) and other serum lipids were not significant in any of the groups. Conclusion: Vitamin E supplementation led to an improvement in the status of serum vitamin E and glycemic control in type 2 diabetic patients. Vitamin E as pertained to the dose and duration throughout this study did not produce any significant difference in other variables. Further studies are suggested to evaluate the possible outcomes of vitamin E on metabolic control in type 2 diabetic patients.</p> Keywords: Vitamin E, Metablic status, Lipoprotein (a), Type 2 diabetes 84 94 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-775&slc_lang=fa&sid=1 Maryam Rafraf مریم رف رف 5200319475328460059364 5200319475328460059364 No Nutrition Research Center, Depat. of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran Behnaz Bazyun بهناز بزیون behnaz_bazyun@yahoo.com 5200319475328460059365 5200319475328460059365 Yes Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran Mohammad Ali Sarabchian محمد‌علی سرابچیان 5200319475328460059366 5200319475328460059366 No Endocrine and Metabolism Section, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Abdorasoul Safaeiyan عبدالرسول صفائیان 5200319475328460059367 5200319475328460059367 No Dept. of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran