fa تاثیر توام بربرین هیدروکلراید و ویتامین E بر اختلالات یادگیری و حافظه در موش‌های صحرایی دیابتی شده با استرپتوزوتوسین کارآزمایی بالینی Clinical Trials <p>Background and Objective: Increasing evidence has shown that diabetes induces cognitive dysfunction and impairs learning and memory. Berberine is an isoquinoline alkaloid and vitamin E is a fat-soluble antioxidant with multiple pharmacological effects on diabetes. Thus, we investigated the effect of Berberine hydrochloride and vitamin E on diabetes-induced cognitive dysfunction in rats. Materials and Methods: 48 male Wistar rats were randomly selected and allocated in 6 control groups: control treated with vitamin E (30mg/kg), diabetic and Berberine-treated diabetic group (100mg/kg), vitamin E-treated diabetic group (30mg/kg) and a diabetic group treated with both vitamin E and Berbrine. Diabetes was induced by STZ administration at dose of 55mg/kg through Intraperitoneal injection route. 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J Intern Med. 1999 245: 99-102.</p> Keywords: Diabetes mellitus, Berberine hydrochloride, Vitamin E, Spatial recognition, Objective recognition 46 58 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-829&slc_lang=fa&sid=1 Hamid Kalalian Moghaddam حمید کلالیان مقدم 5200319475328460059125 5200319475328460059125 No Dept. of Physiology, Faculty of Medicine, Shahrood University of Medical Sciences, Shahrood, Iran Gholam Hosein Vaezi غلامحسن واعظی 5200319475328460059126 5200319475328460059126 No Dept. of Physiology, Islamic Azad University, Damghan, Iran Mahnaz Mesripour Alavijeg مهناز مصری پور علویجه 5200319475328460059127 5200319475328460059127 No Dept. of Physiology, Islamic Azad University, Damghan, Iran Masoumeh salimi معصومه سلیمی Shahrood_alavi@yahoo.com 5200319475328460059128 5200319475328460059128 Yes Dept. of Physiology, Islamic Azad University, Damghan, Iran Fatemeh Ghanbari فاطمه قنبری 5200319475328460059129 5200319475328460059129 No Dept. of Physiology, Islamic Azad University, Damghan, Iran