fa بررسی فراوانی و الگوی مقاومت آنتی‌بیوتیکی ایزوله‌های انتروکوک جدا شده از بیمارستان‌های دولتی شهر زنجان کارآزمایی بالینی Clinical Trials <p dir="ltr" style="text-align: justify"><strong><em>Background and Objective:</em></strong> Enterococci lead to many problems in terms of treatment failure and mortality in patients especially due to antibacterial resistance. Identification of antibiotic resistance in community is of extreme importance to prevent failures particularly in the treatment of infections. Therefore, this study intended to screen antibiotic-resistant enterococci samples from patients.</p> <p dir="ltr" style="text-align: justify"><strong><em>Materials</em></strong><strong> <em>and</em> <em>Methods</em>:</strong> Samples were collected from feces and blood of patients hospitalized over a period of 9 months from July 2013 to March 2014 in Vali-e Asr and Mousavi hospitals. Diagnostic tests such as growth in the presence of bile esculin agar and NaCl 6.5% as well as catalase and Gram staining were performed to verify the samples. Agar disk diffusion method for antibiotic susceptibility testing and microtitre plate assay was performed to evaluate the MIC of vancomycin<span dir="RTL">.</span></p> <p dir="ltr" style="text-align: justify"><strong><em>Results:</em></strong> Among the tested antibiotics, ciprofloxacin showed the highest and teicoplanin as well as vancomycin exhibited the least antibiotic resistance. Interestingly, vancomycin minimum inhibitory concentration was determined 5 to 50 &mug/ml<span dir="RTL">.</span></p> <p dir="ltr" style="text-align: justify"><strong><em>Conclusion: </em></strong>In our study, isolated enterococci from the hospitalized patients showed relatively high resistance to majority of antibiotics. Meanwhile, antibiotic resistance to teicoplanin and vancomycin were acceptable in comparison to other similar studies.</p> <p></p><p dir="ltr" style="text-align: justify"></p><p></p> Keywords: Antibiotic resistance, Enterococci, Zanjan, MIC 36 44 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-901&slc_lang=fa&sid=1 Maryam Hassan مریم حسن mhassan@zums.ac.ir 5200319475328460058834 5200319475328460058834 Yes Pharmaceutical Biotechnology Research Center, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Hosein Jahangiri حسین جهانگیری 5200319475328460058835 5200319475328460058835 No Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Kourosh Kamali کورش کمالی 5200319475328460058836 5200319475328460058836 No Dept. of Food Safety & Hygiene, Faculty of Paramedical & Health Sciences, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Zoya Hojabri زویا هژبری 5200319475328460058837 5200319475328460058837 No Dept. of Microbiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran دانشگاه علوم پزشکی سمنان