fa بررسی فراوانی سرولوژیک هپاتیت A در کودکان مراجعه ‌کننده به بیمارستــان‌های اطفال شهر تهران در سال 1381 مقاله پژوهشی Original Research Article <div style="text-align: justify;"><strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Background:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> Hepatitis A is an enterically transmitted disease that still remains endemic in many developing countries. In some countries improvements in living conditions have recently led to changes in the epidemiology of hepatitis A virus (HAV) infection. This study was performed to determine the serologic frequency of hepatitis A infection among children visited in pediatric hospitals in Tehran, in 2002. </span></span><br> <strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Materials and Methods:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> The study group included 1018 children. These children were visited in four major pediatric hospitals in Tehran. The children were divided into three age groups. Groups 1 (6 months - 4.9 years; n=469), Group 2 (5.0-9.9 years; n=290), and Group 3 (10.0-14.9 years; n=259). The level of serum anti-HAV IgG was measured by commercial ELISA kits in all samples. The data were analyzed with chi-square test. </span></span><br> <strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Results:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;"> In all subjects, serologic frequency of hepatitis A was 22.3% (95% CI: 19.7 - 24.9%). There was no significant difference between boys and girls regarding their seropositivity for HAV (22.2% versus 22.5%). The frequency of hepatitis A infection was not different between three age groups (21.1% group 1, 21% group 2 and 25.9% group 3).</span></span><br> <strong><span style="font-size:18px;"><span style="font-family:Times New Roman;"><span style="color:#ffffff;"><span style="background-color:#16a085;">Conclusions:</span></span></span></span></strong><span style="font-size:16px;"><span style="font-family:Times New Roman;">&nbsp;The epidemiology of hepatitis A has been changed at least in some urban areas in Iran. For prevention of sudden epidemies of hepatitis A due to neighboring of highly contaminated areas, some changes in prophylaxis and immunization methods against hepatitis A are recommended.</span></span></div> HEPATITIS A, EPIDEMIOLOGY, SEROLOGIC EVALUATION 35 39 http://journal.zums.ac.ir/browse.php?a_code=A-10-1-110&slc_lang=fa&sid=1 Mohammadjavad Ehsani Ardekani محمد جواد احسانی اردکانی 5200319475328460069988 5200319475328460069988 Yes Ali Jafarimehr علی جعفری مهر 5200319475328460069989 5200319475328460069989 No Mahdi Hedayati مهدی هدایتی 5200319475328460069990 5200319475328460069990 No Mohammadreza Zali محمد رضا زالی 5200319475328460069991 5200319475328460069991 No