fa اثر عصاره‌ی هیدروالکلی خارمریم (Silybum mariamum) بر جلوگیری از چسبندگی داخل شکمی متعاقب اعمال جراحی در موش صحرایی کارآزمایی بالینی Clinical Trials <p><strong><em>Background and Objective:</em></strong> Adhesion formation is the commonest complication of abdominal surgery. Bearing an anti-oxidant activity, <em>Silybum marianum</em> may reduce adhesion formation. This study was an endeavor to shed light on the effect of <em>Silybum marianum </em>on intra-abdominal adhesions.</p> <p><strong><em>Materials and Methods: </em></strong>In this experimental study, 30 rats were randomly assigned to three groups: treated by 1% and 5% concentrations of the <em>S. marianum </em>extract (groups A and B) and distillated water (group C). After laparotomy, three longitudinal and transverse incisions (2 cm in length) were made on the right wall of the abdomen and a 2&times;2 piece was removed from peritoneal surface on the left side of the abdominal wall. In groups A, B and C, 3 mL of 1% and 5% of <em>S. marianum</em> extract or distillated water were administered into abdominal cavity of the rats, respectively. After 14 days, adhesion degrees were determined according to the number of adhesion bands (Canbaz scale). Data analysis was performed through SPSS 16 using Kruskal-Wallis and Mann-Whitney tests.</p> <p><strong><em>Results: </em></strong>There was a significant difference in adhesion formation among the groups (P=0.023). Adhesion degree in groups A and B were significantly lower than the control group (P<0.05).</p> <p><strong><em>Conclusion:</em></strong> <em>S. marianum</em> extract supported a preventive effect on intra-abdominal adhesion in rats, which gives rise to the evidence that it may be similarly effective for human cases. Throughout further clinical studies, this plant and its derived compounds might be applied in the treatment of such complications subsequent to abdominal surgeries.</p> <p></p> <p><br> &nbsp;</p> <p dir="RTL"></p> Keywords: Intra-abdominal adhesion, Silybum marianum, Rat 32 43 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-913&slc_lang=fa&sid=1 Seyed Yazdan Asadi سید یزدان اسدی 5200319475328460053881 5200319475328460053881 No Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. دانشگاه علوم پزشکی شهرکرد Pouya Parsaei پویا پارسائی 5200319475328460053882 5200319475328460053882 No Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. دانشگاه آزاد اسلامی واحد شهرکرد Soheil Shafiei Alavijeh سهیل شفیعی علویجه 5200319475328460053883 5200319475328460053883 No Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. دانشگاه علوم پزشکی شهرکرد Mahmood Rafieian-kopaei محمود رفیعیان‌کوپائی 5200319475328460053884 5200319475328460053884 No Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran. دانشگاه علوم پزشکی شهرکرد Mehrdad Karimi مهرداد کریمی dr.karimi.mehrdad@gmail.com 5200319475328460053885 5200319475328460053885 Yes Dept of Surgery, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran. دانشگاه علوم پزشکی شهرکرد