fa شیوع سرمی سیتومگالوویروس و هرپس سیمپلکس ویروس در افراد مبتلا به بیماری عروق کرونری قلب کارآزمایی بالینی Clinical Trials <p><strong><em>Background and Objective:</em></strong> Ischemic heart disease implies reduction of oxygen and blood supply in the myocardium. The most common cause of ischemia is atherosclerotic coronary artery disease. While numerous risk factors lead to coronary diseases, the mechanism of infectious agents in CAD remains unidentified.</p> <p><strong><em>Materials and Methods:</em></strong> In this study, 360 patients with and without coronary disease underwent evaluation in terms of cytomegalovirus (CMV) and herpes simplex virus (HSV) seroprevalences. Serology was performed by means of ELISA assays.&nbsp;</p> <p><strong><em>Results: </em></strong>Of 360 patients, positive serology was reported for CMV and HSV in 91.7 % and 93.3% with CAD as well as&nbsp; 66.1 % and 57.5 % without&nbsp; CAD (P<0.001). The risk of coronary disease by cytomegalovirus and herpes simplex in people who had positive serology were 1.5% and 6.81% times, respectively. The risk in regard to the control of other significant variables was statistically significant (P<0.001). The risk of coronary disease pointed out an increase by 3% per age which was statistically significant. In men at risk of coronary artery disease, positive HSV serology was 4.8 times more than women and in patients&nbsp; with a history of myocardial infraction, this risk was reported 6.47 % times more than the patients without&nbsp; this history (P<0.001).&nbsp;</p> <p><strong><em>Conclusion:</em></strong> Owing to possible association of viruses and bacteria in the process of atherosclerosis, furthur research is recommended to find out&nbsp; the relationship of&nbsp; other infectious agents with CAD&nbsp;&nbsp; and the presence of microorganisms in the coronary atherosclerotic specimens.</p> <p></p><p></p><p></p> Keywords: Cytomegalovirus, Cronary artery, Herpes simplex, Seroprevalence 91 101 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-932&slc_lang=fa&sid=1 Afsaneh Karami افسانه کرمی 5200319475328460053847 5200319475328460053847 No Dept. of Infectious Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Sakineh Palizi سکینه پالیزی s-palizi@yahoo.com 5200319475328460053848 5200319475328460053848 Yes Dept. of Nursing, Vali-e-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Hasan Ahangar حسن آهنگر 5200319475328460053849 5200319475328460053849 No Dept. of Cardiology, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Ahmad Jalil Vand احمد جلیلوند 5200319475328460053850 5200319475328460053850 No Dept.of Pathology, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Saeideh Mazloom Zadeh سعیده مظلوم‌زاده 5200319475328460053851 5200319475328460053851 No Dept. of Epidemiology, Social Determinants Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Narges Mohebbi نرگس محبی 5200319475328460053852 5200319475328460053852 No Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان Zoleykha Baiat زلیخا بیات 5200319475328460053853 5200319475328460053853 No Zanjan University of Medical Sciences, Zanjan, Iran دانشگاه علوم پزشکی زنجان