fa تاثیر عصاره‌ی هیدروالکلی گیاه اسطوخودوس بر روی تکثیر و مهار آپوپتوز در سلول‌های بنیادی عصبی موش صحرایی در شرایط آسیب اکسیداتیو ناشی از اتانول کارآزمایی بالینی Clinical Trials <p dir="LTR"><strong><em>Background and Objective:</em></strong> Nowadays, extensive research is carried out on the effect of plant extracts on variety of disorders. In this study, the effect of hydroethanolic extract of <em>Lavandula officinalis</em> on proliferation of neural stem cells as well as its anti-apoptotic properties was assessed.</p> <p dir="LTR"><strong><em>Materials and Methods:</em></strong> Neural stem cells were isolated from hippocampus of neonatal rat brain. To determine the optimal concentration<em> of Lavandula officinalis</em> extract, isolated neural stem cells were treated with 200, 400, 600, 800 and 1000 &micro;g/ml of concentrate for 48 h. Then cell proliferation rate was evaluated via MTT assay. Meanwhile, the anti-apoptotic property of <em>Lavandula officinalis</em> extract was evaluated using TUNEL assay method.&nbsp;</p> <p dir="LTR"><strong><em>Results:</em></strong> The results of this study showed a significant difference in cell proliferative and anti-apoptotic property of <em>Lavandula officinalis</em> extract on neural stem cells comparing to the control group.</p> <p dir="LTR"><strong><em>Conclusion:</em></strong> The hydroethanolic extract of <em>Lavandula officinalis</em> can be effective on proliferation elevation&nbsp; and apoptosis reduction&nbsp; in rat neural stem cells.</p> <p dir="LTR"></p><p dir="LTR"></p><p dir="RTL"></p><p dir="RTL"></p> Keywords: Cell proliferation, Lavandula officinalis, Neural stem cells, Apoptosis, Rat 43 52 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-951&slc_lang=fa&sid=1 Alireza Abdanipour علیرضا عبدانی پور 5200319475328460053488 5200319475328460053488 No Dept. of Anatomy, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. دانشگاه علوم پزشکی زنجان Reza Nejatbakhsh رضا نجات بخش reza_nejat@yahoo.com 5200319475328460053489 5200319475328460053489 Yes Dept. of Anatomy, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. دانشگاه علوم پزشکی زنجان Iraj Jafari Anarkooli ایرج جعفری انارکولی 5200319475328460053490 5200319475328460053490 No Dept. of Anatomy, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. دانشگاه علوم پزشکی زنجان Mehrdad Ghorbanlo مهرداد قربانلو 5200319475328460053491 5200319475328460053491 No Dept. of Anatomy, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. دانشگاه علوم پزشکی زنجان Ali Nikfar علی نیک فر 5200319475328460053492 5200319475328460053492 No Dept. of Genetics and Molecular Medicine, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. دانشگاه علوم پزشکی زنجان Amir Noriyan امبر نوریان 5200319475328460053493 5200319475328460053493 No Young Researchers and Elite Club, Islamic Azad University Ardabil Branch, Ardabil, Iran. دانشگاه آزاد اردبیل