fa بررسی اثر نانو اکسید آهن بر رشد و نمو شش جنین موش نژاد NMRI در شرایط In Vivo کارآزمایی بالینی Clinical Trials <p><strong><em>Background</em></strong> <strong><em>and Objective</em></strong><strong><em><span dir="RTL">:</span></em></strong> Iron oxides nanoparticles have numerous applications in medical industry. Nanoparticles are particles with 100 nm in diameter. Despite their various applications, toxic effects of Iron oxide nanoparticles call for supplementary investigations. In this study, the toxic effect of iron oxide nanoparticles on lung development in fetal mice was examined.</p> <p><strong><em>Materials and Methods:</em></strong> Using in vivo technique, the mice were allocated to one of the following groups: the control group without the effect of nano iron oxide, sham group with injection of distilled water and experimental groups with low doses (10, 30 and 50 &micro;g /kg) and high doses (10, 30 and 30 mg/kg) of nano iron oxide with 20 nm in diameters injected intraperitoneally on day 9 of pregnancy. On day 16 of pregnancy, embryos were removed and the lung tissue sections were assessed.</p> <p><strong><em>Results: </em></strong>The findings showed a significant decrease in the length of the fetus with 30 and 50 mg/kg doses and a significant decrease in the fetal weight and number of primitive bronchioles with 10, 30 and 50 mg/kg. Results &nbsp;also showed a significant increase in lung weight and lung length with doses of 30 and 50 &micro;g/kg, a significant increase in the number of alveolus with doses of 10, 30, 50 &micro;g/kg and 10 mg/kg and a significant increase in the number of necrotic cells &nbsp;with doses of&nbsp; 30 and 50 mg/kg.</p> <p><strong><em>Conclusion:</em></strong> Iron oxide nanoparticles showed dual effects. It is asserted throughout this study that fetal lung development increases at low doses and necrotic effect increases with high doses.</p> <p></p><p></p> Keywords: Iron oxide nanoparticles, Lung development, Toxic effect 94 106 http://journal.zums.ac.ir/browse.php?a_code=A-10-4-979&slc_lang=fa&sid=1 Parvin Khodarahmi پروین خدا رحمی khodarahmiparvin@yahoo.com 5200319475328460053373 5200319475328460053373 Yes Dept. of Biology, Islamic Azad University, Parand Branch, Parand, Iran دانشگاه آزاد اسلامی واحد پرند Nasim Hayati Roodbari نسیم حیاتی رودباری 5200319475328460053374 5200319475328460053374 No Dept. of Biology, Islamic Azad University, Sciences and Research Branch, Tehran, Iran دانشگاه آزاد اسلامی واحد تهران Kazem Parivar کاظم پریور 5200319475328460053375 5200319475328460053375 No Dept. of Biology, Islamic Azad University, Sciences and Research Branch, Tehran, Iran دانشگاه آزاد اسلامی واحد تهران Marjan Sadeghian مرجان صادقیان 5200319475328460053376 5200319475328460053376 No Dept. of Biology, Islamic Azad University, Sciences and Research Branch, Tehran, Iran دانشگاه آزاد اسلامی واحد تهران